Modern logistics is the unsung hero of the development of E-business, and cross-border E-business and cross-border logistics are interdepend. Based on the analysis of the development background and significance of cross-border E-business, this article put forward the main bottlenecks in the development of cross-border E-business:customs clearance formalities, cross-border logistics operations and credit and payment security, etc. And under the guidance of supply chain, the targeted countermeasures are put forward.%现代物流是电子商务迅猛发展的幕后英雄，跨境电商同样与跨境物流相互依存。文章在分析跨境电商发展背景及意义的基础上，提出其发展过程中的主要瓶颈：清关手续、跨境物流运营和信用及支付安全等，并在供应链理念指导下，有针对性地提出应对策略。
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