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首页> 中文期刊> 《世界临床病例杂志》 >Relationship between lipids and sleep apnea: Mendelian randomization analysis

Relationship between lipids and sleep apnea: Mendelian randomization analysis

         
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BACKGROUND Lipids increase the risk of sleep apnea;however,the causality between them is still inconclusive.AIM To explore the causal relationship between serum lipids and sleep apnea using two-sample Mendelian randomization(MR)analysis.METHODS Single nucleotide polymorphism(SNP)data related to serum lipids were obtained from the Global Lipids Genetics Consortium study,which included 188578 individuals of European ancestry.Additionally,sleep apnea-related SNP data were collected from the United Kingdom Biobank study,which comprised 463005 individuals of European ancestry.Two-sample MR analysis was performed to assess the causality between serum lipids and sleep apnea based on the above public data.RESULTS Genetically predicted low-density lipoprotein(odds ratio[OR]=0.99,95%confidence interval[CI]=0.99 to 1.00;P=0.58),high-density lipoprotein(OR=0.99,95%CI=0.99 to 1.00;P=0.91),triglyceride(OR=1.00,95%CI=0.99 to 1.00;P=0.92),and total cholesterol(OR=0.99,95%CI=0.99 to 1.00;P=0.33)were causally unrelated to sleep apnea.CONCLUSION Our MR analysis suggests that genetically predicted serum lipids are not risk factors of sleep apnea.

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