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首页> 中文期刊> 《世界临床病例杂志》 >Effectiveness of adjunctive corticosteroid therapy in patients with severe COVID-19:A retrospective cohort study

Effectiveness of adjunctive corticosteroid therapy in patients with severe COVID-19:A retrospective cohort study

         
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摘要

BACKGROUND The effectiveness of adjunctive corticosteroid use in patients with coronavirus disease 2019(COVID-19)remains inconclusive.AIM To investigate the effectiveness of adjunctive corticosteroid therapy in patients with severe COVID-19.METHODS We conducted a retrospective analysis of the difference in several outcomes between patients with severe COVID-19 who received corticosteroid therapy(the corticosteroid group)and patients with severe COVID-19 who did not receive corticosteroid therapy(the non-corticosteroid group).RESULTS Seventy-five patients were included in this study.Of these,47 patients were in the corticosteroid group and 28 patients were in the non-corticosteroid group.There were no differences between the two groups in the total length of hospital stay,the length of intensive care unit stay,high-flow oxygen days,non-invasive ventilator days,invasive ventilation days,and mortality rate.Total lesion volume ratio,consolidation volume ratio and ground-glass opacity volume ratio in the corticosteroid group decreased significantly on day 14,while those in the noncorticosteroid group did not show a significant decrease.CONCLUSION Our results show that adjunctive corticosteroid use did not significantly improveclinical outcomes in severe COVID-19 patients,but might promote the absorptionof pulmonary lesions.Larger multicenter randomized controlled studies may beneeded to confirm this.

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  • 来源
    《世界临床病例杂志》 |2021年第15期|P.3546-3558|共13页
  • 作者

    Bin Xiong; Li-Min He; Yuan-Yuan Qin; Hu Du; Zhu Zhan; Yi-Hong Zhou; Yao-Kai Chen; An Zhang;

  • 作者单位

    Department of Critical Care Medicine The Second Affiliated Hospital of Chongqing Medical University Chongqing 400010 China;

    Department of Cardiology The First Branch of The First Affiliated Hospital Chongqing Medical University Chongqing 400015 China;

    Division of Infectious Diseases Chongqing Public Health Medical Center Chongqing 400036 China;

    Department of Critical Care Medicine The Second Affiliated Hospital of Chongqing Medical University Chongqing 400010 China;

    Department of Critical Care Medicine The Second Affiliated Hospital of Chongqing Medical University Chongqing 400010 China;

    Division of Infectious Diseases Chongqing Public Health Medical Center Chongqing 400036 China;

    Division of Infectious Diseases Chongqing Public Health Medical Center Chongqing 400036 China;

    Department of Critical Care Medicine The Second Affiliated Hospital of Chongqing Medical University Chongqing 400010 China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 肿瘤学;
  • 关键词

    COVID-19; Corticosteroid; SARS-CoV-2; Outcomes;

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