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首页> 中文期刊> 《世界临床病例杂志》 >Lymphocytic choriomeningitis virus:An under-recognized congenital teratogen

Lymphocytic choriomeningitis virus:An under-recognized congenital teratogen

         
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BACKGROUND Lymphocytic choriomeningitis virus(LCMV)is a neglected rodent-borne arenavirus associated with transplacental transmission and fetal infection.AIM To summarize the epidemiological,clinical,and diagnostic features of reported patients with congenital LCMV infection.METHODS A literature search was conducted in PubMed,Medline,Google Scholar,and ResearchGate.The keywords used were‘congenital lymphocytic choriomeningitis virus,’and 48 studies were included.In addition,we conducted a relevant search by Reference Citation Analysis(RCA)(https://www.referencecitationan alysis.com).RESULTS The results have shown 27 reports of congenital LCMV infection in 86 patients,with 52.73%of them being males.Patients presented with chorioretinitis(83.53%),hydrocephalus(54.12%),and psychomotor retardation or developmental delay(54.12%).Computed tomography and/or magnetic resonance imaging most often demonstrated ventriculomegaly(74.07%),periventricular calcifications(66.67%),and microcephaly(40%).Most mothers of congenitally infected infants were exposed to rodents during pregnancy,predominantly mice,with flu-like symptoms mainly occurring during the first two trimesters of gestation.Mortality in congenitally infected children was 16.47%.The diagnosis of congenital LCMV infection was confirmed serologically in most patients(86.67%).CONCLUSION LCMV is still an insufficiently recognized fetal teratogen that often leads to long-term neurologic sequelae.Clinicians need to be familiar with LCMV and its potential teratogenic effect and as well as to effectively differentiate LCMV from other TORCH(T:Toxoplasma gondii,O:Other pathogens,R:Rubella virus,C:Cytomegalovirus,H:Herpes simplex virus)pathogens.

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