Development of septic shock and prognosticassessment in critically ill patients with coronavirus disease outside Wuhan, China

Ren-qi Yao; Yong-wen Feng; Yong-ming Yao; Chao Ren; Di Ren; Jin-xiu Li; Ying Li; Xue-yan Liu; Lei Huang; Yong Liu; Mian Peng

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Development of septic shock and prognosticassessment in critically ill patients with coronavirus disease outside Wuhan, China

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BACKGROUND: The study aims to illustrate the clinical characteristics and development of septic shock in intensive care unit(ICU) patients confirmed with severe acute respiratory syndrome coronavirus 2(SARS-Co V-2) infection, and to perform a comprehensive analysis of the association between septic shock and clinical outcomes in critically ill patients with coronavirus disease(COVID-19).METHODS: Patients confirmed with SARS-Co V-2 infection, who were admitted to the ICU of the Third People's Hospital of Shenzhen from January 1 to February 7, 2020, were enrolled. Clinical characteristics and outcomes were compared between patients with and without septic shock.RESULTS: In this study, 35 critically ill patients with COVID-19 were included. Among them, the median age was 64 years(interquartile range [IQR] 59-67 years), and 10(28.4%) patients were female. The median ICU length of stay was 16 days(IQR 8-23 days). Three(8.6%) patients died during hospitalization. Nine(25.7%) patients developed septic shock in the ICU, and these patients had a significantly higher incidence of organ dysfunction and a worse prognosis than patients without septic shock.CONCLUSIONS: Septic shock is associated with a poor outcome in critically ill COVID-19 patients and is one of the hallmarks of the severity of patients receiving ICU care. A dysregulated immune response, uncontrolled infl ammation, and coagulation disorders are strongly associated with the development and progression of COVID-19-related septic shock.

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《世界急诊医学杂志（英文）》 |2021年第004期|293-298|共6页
作者
Ren-qi Yao; Yong-wen Feng; Yong-ming Yao; Chao Ren; Di Ren; Jin-xiu Li; Ying Li; Xue-yan Liu; Lei Huang; Yong Liu; Mian Peng;
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Department of Critical Care Medicine the Second People's Hospital of Shenzhen Shenzhen 518035 China;

Trauma Research Center the Fourth Medical Center and Medical Innovation Research Department of the Chinese PLA General Hospital Beijing 100048 China;

Department of Critical Care Medicine the Second People's Hospital of Shenzhen Shenzhen 518035 China;

Department of Critical Care Medicine the Second People's Hospital of Shenzhen Shenzhen 518035 China;

Trauma Research Center the Fourth Medical Center and Medical Innovation Research Department of the Chinese PLA General Hospital Beijing 100048 China;

Department of Critical Care Medicine the Second People's Hospital of Shenzhen Shenzhen 518035 China;

Trauma Research Center the Fourth Medical Center and Medical Innovation Research Department of the Chinese PLA General Hospital Beijing 100048 China;

Department of Critical Care Medicine the Second People's Hospital of Shenzhen Shenzhen 518035 China;

Department of Critical Care Medicine the Third People's Hospital of Shenzhen Shenzhen 518020 China;

Department of Critical Care Medicine the Third People's Hospital of Shenzhen Shenzhen 518020 China;

Department of Critical Care Medicine the Second People's Hospital of Shenzhen Shenzhen 518035 China;

Department of Critical Care Medicine the People's Hospital of Shenzhen Shenzhen 518020 China;

Department of Critical Care Medicine Peking University Shenzhen Hospital Shenzhen 518035 China;

Department of Critical Care Medicine Shenzhen Hospital of Southern Medical University Shenzhen 518110 China;

Department of Critical Care Medicine the Third Affiliated Hospital of Shenzhen University Shenzhen 518001 China;

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Development of septic shock and prognosticassessment in critically ill patients with coronavirus disease outside Wuhan, China

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