Outcomes of severe sepsis and septic shock patients after stratifi cation by initial lactate value

Kimberly A. Chambers; Adam Y. Park; Rosa C. Banuelos; Bryan F. Darge; Bindu H. Akkanti; Annamaria Macaluso; Manoj Thangam; Pratik B. Doshi

首页> 中文期刊> 《世界急诊医学杂志(英文版)》 >Outcomes of severe sepsis and septic shock patients after stratifi cation by initial lactate value

Outcomes of severe sepsis and septic shock patients after stratifi cation by initial lactate value

开具论文收录证明 >>

期刊封面封底目录下载 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

BACKGROUND： In the setting of severe sepsis and septic shock, mortality increases when lactatelevels are ! 4 mmol/L. However, the consequences of lower lactate levels in this population are not wellunderstood. The study aimed to determine the in-hospital mortality associated with severe sepsis andseptic shock when initial lactate levels are 〈 4 mmol/L.METHODS： This is a retrospective cohort study of septic patients admitted over a 40-monthperiod. Totally 338 patients were divided into three groups based on initial lactate values. Group 1had lactate levels 〈 2 mmol/L; group 2： 2-4 mmol/L; and group 3： ! 4 mmol/L. The primary outcomewas in-hospital mortality.RESULTS： There were 111 patients in group 1, 96 patients in group 2, and 131 in group 3. Themortality rates were 21.6%, 35.4%, and 51.9% respectively. Univariate analysis revealed the mortalitydifferences to be statistically signifi cant. Multivariate logistic regression demonstrated higher odds ofdeath with higher lactate tier group, however the fi ndings did not reach statistical signifi cance.CONCLUSION： This study found that only assignment to group 3, initial lactic acid level of! 4 mmol/L, was independently associated with increased mortality after correcting for underlyingseverity of illness and organ dysfunction. However, rising lactate levels in the other two groups wereassociated with increased severity of illness and were inversely proportional to prognosis.

著录项

来源
《世界急诊医学杂志(英文版)》 |2018年第2期|P.113-117|共5页
作者
Kimberly A. Chambers; Adam Y. Park; Rosa C. Banuelos; Bryan F. Darge; Bindu H. Akkanti; Annamaria Macaluso; Manoj Thangam; Pratik B. Doshi;
展开▼
作者单位

[1]Department of Emergency Medicine;

McGovern Medical School at UTHealth;

Houston;

TX;

USA;

[2]McGovern Medical School at UTHealth;

Houston;

TX;

USA;

[2]McGovern Medical School at UTHealth;

Houston;

TX;

USA;

[4]Department of Emergency Medicine;

University of California;

San Francisco;

CA;

USA;

[3]Division of Critical Care;

Department of Internal Medicine;

McGovern Medical School at UTHealth;

Houston;

TX;

USA;

[5]Memorial Hermann Hospital - Texas Medical Center;

Houston;

TX;

USA;

[6]Department of Internal Medicine;

McGovern Medical School at UTHealth;

Houston;

TX;

USA;

[1]Department of Emergency Medicine;

McGovern Medical School at UTHealth;

Houston;

TX;

USA;

[2]McGovern Medical School at UTHealth;

Houston;

TX;

USA;

[3]Division of Critical Care;

Department of Internal Medicine;

McGovern Medical School at UTHealth;

Houston;

TX;

USA;

展开▼
原文格式 PDF
正文语种 CHI
中图分类文化、科学、教育、体育;
关键词
Sepsis; Lactic; acid; Emergency; medicine;

机译：脓毒症;乳酸;酸;紧急情况;药物;

Outcomes of severe sepsis and septic shock patients after stratifi cation by initial lactate value

摘要

著录项

相关主题

期刊订阅