• 主题
高级搜索  >
历史搜索 清空历史
首页> 中文期刊> 《世界急诊医学杂志(英文版)》 >Role of penehyclidine in acute organophosphorus pesticide poisoning

Role of penehyclidine in acute organophosphorus pesticide poisoning

         
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

cqvip:BACKGROUND:Penehyclidine is a newly developed anticholinergic agent.We aimed to investigate the role of penehyclidine in acute organophosphorus pesticide poisoning(OP)patients.METHODS:We searched the Pubmed,Cochrane library,EMBASE,Chinese National Knowledge Infrastructure(CNKI),Chinese Biomedical literature(CBM)and Wanfang databases.Randomized controlled trials(RCTs)recruiting acute OP patients were identifi ed for meta-analysis.Main outcomes included cure rate,mortality rate,time to atropinization,time to 60%normal acetylcholinesterase(AchE)level,rate of intermediate syndrome(IMS)and rate of adverse drug reactions(ADR).RESULTS:Sixteen RCTs involving 1,334 patients were identifi ed.Compared with the atropineor penehyclidine-alone groups,atropine combined with penehyclidine significantly increased the cure rate(penehyclidine+atropine vs.atropine,0.97 vs.0.86,RR 1.13,95%CI[1.07–1.19];penehyclidine+atropine vs.penehyclidine,0.93 vs.0.80,RR 1.08,95%CI[1.01–1.15])and reduced the mortality rate(penehyclidine+atropine vs.atropine,0.015 vs.0.11,RR 0.17,95%CI[0.06–0.49];penehyclidine+atropine vs.penehyclidine,0.13 vs.0.08,RR 0.23,95%CI[0.04–1.28]).Atropine combined with penehyclidine in OP patients also helped reduce the time to atropinization and AchE recovery,the rate of IMS and the rate of ADR.Compared with a single dose of atropine,a single dose of penehyclidine also signifi cantly elevated the cure rate,reduced times to atropinization,AchE recovery,and rate of IMS.CONCLUSION:Atropine combined with penehyclidine benefi ts OP patients by enhancing the cure rate,mortality rate,time to atropinization,AchE recovery,IMS rate,total ADR and duration of hospitalization.Penehyclidine combined with atropine is likely a better initial therapy for OP patients than atropine alone.

著录项

  • 来源
    《世界急诊医学杂志(英文版)》 |2020年第1期|P.37-47|共11页
  • 作者

    Shi-yuan Yu; Yan-xia Gao; Joseph Walline; Xin Lu; Li-na Zhao; Yuan-xu Huang; Jiang Tao; An-yong Yu; Na Ta; Ren-ju Xiao; Yi Li;

  • 作者单位

    Department of Emergency Medicine Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China;

    Department of Emergency Medicine the First Affi liated Hospital of Zhengzhou University Zhengzhou China;

    Accident and Emergency Medicine Academic Unit Prince of Wales Hospital the Chinese University of Hong Kong Hong Kong China;

    Department of Emergency Medicine the Fourth Affi liated Hospital of Jishou University Huaihua China;

    Department of Emergency Medicine the First Affi liated Hospital of Zunyi Medical University Zunyi China;

    Department of Emergency Medicine Chifeng Municipal Hospital Chifeng China;

    Department of Emergency Medicine Xingyi People''s Hospital Xingyi China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 TN9;
  • 关键词

    Penehyclidine; Organophosphorus pesticide poisoning; Meta-analysis;

    机译：苯乙啶;有机磷农药中毒;荟萃分析;
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号