Biomarkers for gastrointestinal adverse events related to thiopurine therapy

Giulia Zudeh; Raffaella Franca; Gabriele Stocco; Giuliana Decorti

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Biomarkers for gastrointestinal adverse events related to thiopurine therapy

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Thiopurines are immunomodulators used in the treatment of acute lymphoblastic leukemia and inflammatory bowel diseases.Adverse reactions to these agents are one of the main causes of treatment discontinuation or interruption.Myelosuppression is the most frequent adverse effect;however,approximately 5%-20%of patients develop gastrointestinal toxicity.The identification of biomarkers able to prevent and/or monitor these adverse reactions would be useful for clinicians for the proactive management of long-term thiopurine therapy.In this editorial,we discuss evidence supporting the use of PACSIN2,RAC1,and ITPA genes,in addition to TPMT and NUDT15,as possible biomarkers for thiopurine-related gastrointestinal toxicity.

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《世界胃肠病学杂志：英文版》 |2021年第38期|6348-6356|共9页
作者
Giulia Zudeh; Raffaella Franca; Gabriele Stocco; Giuliana Decorti;
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作者单位

Department of Life Sciences;

University of Trieste;

Trieste 34127;

Italy;

Department of Medical;

Surgical and Health Sciences;

University of Trieste;

Trieste 34149;

Italy;

Institute for Maternal and Child Health I.R.C.C.S Burlo Garofolo;

Trieste 34137;

Italy;

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原文格式 PDF
正文语种 chi
中图分类肿瘤学;
关键词
Thiopurines; Gastrointestinal adverse effects; Biomarkers; PACSIN2; RAC1; ITPA;

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Biomarkers for gastrointestinal adverse events related to thiopurine therapy

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