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中文期刊>世界胃肠病学杂志：英文版
>Clinicopathological significance of B-cell-specific Moloney murine leukemia virus insertion site 1 expression in gastric carcinoma and its precancerous lesion
Clinicopathological significance of B-cell-specific Moloney murine leukemia virus insertion site 1 expression in gastric carcinoma and its precancerous lesion
AIM: To explore the relation between B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi-1) expression and the clinicopathological features of gastric carcinoma (GC). METHODS: Immunohistochemistry was used to detect the expression of Bmi-1 and ki-67. Double-labeling staining was used to display the distribution of Bcl-2+/ki-67- cells in 162 cases of GC and its matched normal mucosa and precancerous lesion. RESULTS: The positive rate of Bmi-1 expression in GC (52.5%) was significantly higher than that in normal gastric mucosa (21.6%, χ2 = 33.088, P < 0.05). The Bmi-1 expression in GC was closely related with the Lauren's and Borrmann's classification and clinical stage (χ2 = 4.400, 6.122 and 11.190, respectively, P < 0.05). The expression of ki-67 was related to the Borrmann's classification (χ2 = 13.380, P < 0.05). Bcl-2 expression was correlated with the Lauren's classification (χ2 = 4.725, P < 0.05), and the Bmi-1expression both in GC (rk = 0.157, P < 0.05) and in intestinal metaplasia (rk = 0.270, P < 0.05). CONCLUSION: Abnormal Bmi-1 expression in GC may be involved in cell proliferation, apoptosis and cancerization. This marker can objectively indicate the clinicopathological characteristics of GC.
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The Fourth Laboratory of Cancer Institute, Department of Tumor Pathology of General Surgery Institute, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China;
