Large-duct pattern invasive adenocarcinoma of the pancreas–a variant mimicking pancreatic cystic neoplasms: A minireview

Hiroki Sato; Andrew Scott Liss; Yusuke Mizukami

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Large-duct pattern invasive adenocarcinoma of the pancreas–a variant mimicking pancreatic cystic neoplasms: A minireview

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Pancreatic cancer currently has no subtypes that inform clinical decisions;hence,there exists an opportunity to rearrange the morphological and molecular taxonomy that guides a better understanding of tumor characteristics.Nonetheless,accumulating studies to date have revealed the large-duct type variant,a unique subtype of pancreatic ductal adenocarcinoma(PDA)with cystic features.This subtype often radiographically mimics intraductal papillary mucinous neoplasms(IPMNs)and involves multiple small cysts occasionally associated with solid masses.The“bunch-of-grapes”sign,an imaging characteristic of IPMNs,is absent in large-duct PDA.Large-duct PDA defines the mucin profile,and genetic alterations are useful in distinguishing large-duct PDA from IPMNs.Histologically,neoplastic ducts measure over 0.5 mm,forming large ductal elements.Similar to classic PDAs,this subtype is frequently accompanied by perineural invasion and abundant desmoplastic reactions,and KRAS mutations in codon 12 are nearly ubiquitous.Despite such morphological similarities with IPMNs,the prognosis of large-duct PDA is equivalent to that of classic PDA.Differential diagnosis is therefore essential.

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《世界胃肠病学杂志：英文版》 |2021年第23期|3262-3278|共17页
作者
Hiroki Sato; Andrew Scott Liss; Yusuke Mizukami;
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作者单位

Division of Gastroenterology and Hematology/Oncology;

Department of Medicine;

Asahikawa Medical University;

Asahikawa 0788510;

Hokkaido;

Japan;

Department of Surgery;

Massachusetts General Hospital and Harvard Medical School;

Massachusetts General Hospital;

Boston;

MA 02114;

United States;

Institute of Biomedical Research;

Sapporo Higashi Tokushukai Hospital;

Sapporo 0650033;

Hokkaido;

Japan;

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原文格式 PDF
正文语种 chi
中图分类肿瘤学;
关键词
Large-duct pattern invasive carcinoma of the pancreas; Pancreatic ductal adenocarcinoma; Pancreatic cystic disease; Clinicopathological features of pancreatic cancer; Pancreatic cancer subtype;

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Large-duct pattern invasive adenocarcinoma of the pancreas–a variant mimicking pancreatic cystic neoplasms: A minireview

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