Treatment of eosinophlic esophagitis with swallowed topical corticosteroids

Simon Nennstiel; Christoph Schlag

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Treatment of eosinophlic esophagitis with swallowed topical corticosteroids

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Eosinophilic esophagitis(EoE)is an emerging chronic local immune-mediated disease of the esophagus.Beside proton pump inhibitors and food-restrictiondiets swallowed topical corticosteroids(STC)can be offered as a first line therapy according to current guidelines.This review describes the background and practical management of STCs in EoE.So far,mainly asthma inhalers containing either budesonide or fluticasone have been administered to the esophagus by swallowing these medications“off label”.Recently esophagus-targeted formulations of topical steroids have been developed showing clinicopathological response rates up to 85%-an orodispersible tablet of budesonide has been approved as the first“in label”medication for EoE in Europe in June 2018.Whereas it was shown that disease remission induction of EoE by STCs is highly effective,there is still a lack of data regarding long-term and maintenance therapy.However,current studies on STC maintenance therapy add some movement into the game.

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《世界胃肠病学杂志：英文版》 |2020年第36期|5395-5407|共13页
作者
Simon Nennstiel; Christoph Schlag;
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作者单位

Klinikum rechts der Isar der Technischen Universität München;

Klinik und Poliklinik für Innere Medizin II;

Munich 81675;

Germany;

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原文格式 PDF
正文语种 chi
中图分类消化系及腹部疾病;
关键词
Eosinophilic esophagitis; Swallowed topical corticosteroids; Esophagustargeted formulations of topical steroids; Fluticasone; Budesonide; Budesonide orodispersible tablet; Budesonide oral suspension;

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Treatment of eosinophlic esophagitis with swallowed topical corticosteroids

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