首页> 中文期刊> 《世界胃肠病学杂志:英文版》 >Early prediction of major depression in chronic hepatitis C patients during peg-interferon α-2b treatment by assessment of vegetative-depressive symptoms after four weeks

Early prediction of major depression in chronic hepatitis C patients during peg-interferon α-2b treatment by assessment of vegetative-depressive symptoms after four weeks

         

摘要

AIM: To study the predictive value of the vegetative- depressive symptoms of the Zung Depression Rating Scale for the occurrence of depression during treatment with peg-interferon α-2b of chronic hepatitis C (CHC) patients. METHODS: The predictive value of vegetative- depressive symptoms at 4 wk of treatment for the occurrence of a subsequent diagnosis of major depressive disorder (MDD) was studied in CHC patients infected after substance use in a prospective, multi- center treatment trial in Belgium. The presence of vegetative-depressive symptoms was assessed using the Zung Scale before and 4 wk after the start of antiviral treatment. RESULTS: Out of 49 eligible patients, 19 (39%) developed MDD. The area under the ROC curve of the vegetative Zung subscale was 0.73, P = 0.004. The sensitivity at a cut-point of > 15/35 was 95% (95% CI: 74-100). The positive predictive value equalled 44% (95% CI: 29-60). CONCLUSION: In this group of Belgian CHC patients infected after substance use, antiviral treatment caused a considerable risk of depression. Seven vegetativedepressive symptoms of the Zung scale at wk 4 of treatment predicted 95% of all emerging depressions, at a price of 56% false positive test results.

著录项

  • 来源
    《世界胃肠病学杂志:英文版》 |2007年第43期|5736-5740|共5页
  • 作者单位

    Department of Gastroenterology and Hepatology;

    Ziekenhuis Oost Limburg;

    Genk;

    Belgium;

    Department of Psychiatry;

    Ziekenhuis Oost Limburg;

    Genk;

    Belgium;

    Department of Psychiatry and Neuro-psychiatry;

    South Limburg Mental Health Research and Teaching Network;

    EURON;

    Maastricht University;

    Maastricht;

    The Netherlands;

    Center for Statistics;

    Limburgs Universitair Centrum;

    Diepenbeek;

    Belgium;

    Department of Hepatology;

    Katholieke Universiteit Leuven;

    Leuven;

    Belgium;

    Division of Gastroenterology and Hepatology;

    University Hospital;

    Antwerp;

    Belgium;

    Laboratory of Clinical and Epidemiological Virology;

    Department of Microbiology and Immunology;

    Rega Institute and University Hospitals;

    Katholieke Universiteit Leuven;

    Leuven;

    Belgium;

    Department of General Practice;

    Katholieke Universiteit Leuven;

    Leuven;

    Belgium and Department of General Practice;

    Maastricht University;

    The Netherlands;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 肝炎;
  • 关键词

    干扰素; 丙肝; 康复治疗; 预后;

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