Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors:Pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take'toll'?

Peter Laszlo Lakatos; Simon Fischer; Janos Papp; Laszlo Lakatos; Istvan Gal

首页> 中文期刊> 《世界胃肠病学杂志：英文版》 >Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors:Pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take'toll'?

Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors:Pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take'toll'?

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摘要

煽动性的肠疾病(IBD ) 的致病仅仅部分被理解。各种各样环境并且主人(例如基因 -- ，上皮 -- ，有免疫力、非有免疫力) 因素被包含。它是有可能的基因异质的多因素的复合基因疾病。一些基因自己与 IBD 被联系，当其它增加 ulcerative (UC ) 或 Crohn 的疾病(CD ) 的风险或与疾病地点或行为被联系时。这评论在 IBD 的遗传探讨最近的进展。文章在在微生物引起、基因的因素之间的串音上讨论当前的信息(例如 NOD2/CARD15， SLC22A46A5 和 DLG5 ) 。在理解 IBD 和罐头的致病在最近的年帮助获得的基因数据为治疗学的干预识别很多个潜在的目标。以后，遗传可以更精确地帮助在 IBD 诊断并且预言疾病路线。

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来源
《世界胃肠病学杂志：英文版》 |2006年第12期|1829-1841|共13页
作者
Peter Laszlo Lakatos; Simon Fischer; Janos Papp; Laszlo Lakatos; Istvan Gal;
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作者单位

Department of Medicine;

Semmelweis University;

Budapest;

Hungary;

Department of Medicine;

Csolnoky F.County Hospital;

Veszprem;

Hungary;

Department of Medicine;

Kenezi Gy.County Hospital;

Debrecen;

Hungary;

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原文格式 PDF
正文语种 chi
中图分类消化系及腹部疾病;
关键词
电流; 病理机制; 炎症; 遗传因素; 微生物; 肠黏膜;

Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors:Pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take'toll'?

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