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《世界中西医结合杂志（英文）》
>Effects of Bazhen Pills on Quality of Life and Immune Function of Postoperative Chemotherapy in Patients with Gallbladder Cancer
Effects of Bazhen Pills on Quality of Life and Immune Function of Postoperative Chemotherapy in Patients with Gallbladder Cancer
cqvip:OBJECTIVE: To investigate the effects of Bazhen Pills on quality of life and immune function of patients undergoing chemotherapy after gallbladder cancer surgery. METHODS: A total of 64 patients with gallbladder cancer treated by surgery and postoperative basic nutritional support and symptomatic treatment in our hospital were selected and randomly divided into the control group and the observation group, with 32 cases in each group.The control group was treated with chemotherapy from 4^(th) to 6^(th) week after surgery. The observation group was treated by Bazhen Pills on the basis of the treatment in the control group. The blood cell count, immune function,TCM symptom scores, KPS scores, quality of life and adverse reactions were compared between the 2 groups.RESULTS: The WBC and PLT in 2 groups were decreased after the treatment, and the data in the observation group were higher than that in the control group(P < 0.05). The levels of CD3^+, CD4^+ and CD8^+ in the 2 groups were increased after the treatment(P < 0.05), and the data in the observation group were higher than that in the control group(P < 0.05). TCM syndrome scores of the 2 groups were decreased after the treatment(P < 0.05),and the KPS scores were increased after the treatment(P < 0.05). The improvement degrees of the 2 scores in the observation group were higher than that of the control group(P < 0.05). The fatigue symptom scores of the 2 groups were decreased while scores of physical function, role function and overall health were increased after the treatment(P < 0.05). The scores of the observation group were better than those of the control group(P < 0.05). The total incidence of grade I-II hematological toxicity and grade I-II gastrointestinal reactions in the observation group was lower than that in the control group(21.88% vs 50.00%)(P < 0.05). CONCLUSION: Bazhen Pills can effectively relieve clinical symptoms of patients undergoing chemotherapy after gallbladder cancer surgery, and improve their immune function and quality of life, with safety.
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