Meta-analysis about Western Medicine combined with activating blood drugs on modulating blood glucose and lipids in diabetic patients

Huang Suping; Kang Wenqian; Huang Bowei; Heng Xianpei; Qiu Caixia; Lin Miaoxian; Chen Longhui; Yan Qunfang; Chen Chaoyun; Wang Simei; Ye Mengjie; Zheng Hulin

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Meta-analysis about Western Medicine combined with activating blood drugs on modulating blood glucose and lipids in diabetic patients

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OBJECTIVE: To assess the effect of activating blood drugs (AB drugs) on blood glucose and lipid levels of diabetic patients. METHODS: Systematic searches were conducted on 6 electronic databases and the search time was cut off in May 2016. Randomized controlled trials (RCTs) were included if they investigated diabetic patients who received Western medicine combined with AB drugs in the experimental groups and solitary usage of corresponding Western medicine or placebo in the control groups. 6 outcome measures, which were considered as inclusion, were changes in fasting blood glucose (FBG), glycosylated haemoglobin A1c (HbA1c), total triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c) and high density lipoprotein cholesterol (HDL-c). The literature quality was assessed by Cochrane score for risk of bias in Review Manager 5.2, as well as meta-analysis was performed. RESULTS: 7 RCTs comprising 999 patients met all inclusion criteria. Meta-analysis showed beneficial effects of Western medicine combined with AB drugs on modulating FBG, TC, LDL-c and HDL-c compared with Western medicine or placebo (P<0.05), while no difference was observed in HbA1c, and TG (P>0.05). To some extent, the therapeutic effects of Western medicine combined with AB drugs were better than that of solitary usage of Western medicine or placebo. Besides, AB drugs were safe and reliable with little toxic and side-effects. CONCLUSIONS: The meta-analysis suggests beneficial effects of Western medicine combined with AB drugs on modulating blood glucose and lipids in diabetic patients.

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《世界中西医结合杂志（英文）》 |2016年第003期|8-14|共7页
作者
Huang Suping; Kang Wenqian; Huang Bowei; Heng Xianpei; Qiu Caixia; Lin Miaoxian; Chen Longhui; Yan Qunfang; Chen Chaoyun; Wang Simei; Ye Mengjie; Zheng Hulin;
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作者单位

Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China;

Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China;

Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China;

The People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350004, China;

Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China;

The People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350004, China;

Xiamen Heshan Street Community Health Service Center, Xiamen 361015, China;

Pi-Wei Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China;

Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China;

Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China;

Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China;

Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China;

Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China;

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Meta-analysis about Western Medicine combined with activating blood drugs on modulating blood glucose and lipids in diabetic patients

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