Using the Box–Behnken Response Surface Method to Optimize the Preparation and Characterization of Lavender and Fennel Volatile oil β-cyclodextrin Form Inclusion Complex

Yuan-Yuan Liu; Guo-Song Zhang; Guang-Wei Zhu; Ai-Ni-Wa-Er Aikemu; Jia-Jia Ai; Dong-Xun Li

首页> 中文期刊> 《世界中医药杂志（英文版）》 >Using the Box–Behnken Response Surface Method to Optimize the Preparation and Characterization of Lavender and Fennel Volatile oil β-cyclodextrin Form Inclusion Complex

Using the Box–Behnken Response Surface Method to Optimize the Preparation and Characterization of Lavender and Fennel Volatile oil β-cyclodextrin Form Inclusion Complex

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Objective: The objective of this study is to study the best inclusion technology of Lavender- and fennel-mixed volatile oil by beta?cyclodextrin (β-CD) and characterize the final product thereafter. Methods: Using the saturated water solution method, the volatileβ-CD inclusion complex was produced. The effect of volatile oil weight ratio, inclusion temperature and inclusion time on the inclusive quality was studied by measuring the yield of inclusion and inclusion rate of volatile oil as evaluation indexes. The preparation method of inclusion complex was then optimized by the Box-Behnken response surface method. The inclusion complex was characterized by ultraviolet spectrophotometry, thin-layer chromatography, thermogravimetry and differential thermal analysis, and the microscopic imaging method. Results: The optimized conditions were the weight ratio of β-CD to volatile oil was 8.13:1 (g/ml). The inclusion temperature was 44℃. The inclusion time was 1 h. Conclusion: We were able to produce an inclusion complex with high inclusion rate of volatile oil and high yield of inclusion using the preparation method mentioned above. Furthermore, the method can also improve the stability of volatile oil in abnormal savda munziq. This study can provide a good reference for the development of new preparations.

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《世界中医药杂志（英文版）》 |2018年第2期|54-61|共8页
作者
Yuan-Yuan Liu; Guo-Song Zhang; Guang-Wei Zhu; Ai-Ni-Wa-Er Aikemu; Jia-Jia Ai; Dong-Xun Li;
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aThe National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Jiangxi, Nanchang 330006;

aThe National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Jiangxi, Nanchang 330006;

bChinese Medicine Research Institute, Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences, Dongzhimen, Dongcheng District, Beijing 100700;

cBasic Medical College, Xinjiang Medical University, Xinjiang, Wulumuqi 830011, China;

aThe National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Jiangxi, Nanchang 330006;

aThe National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Jiangxi, Nanchang 330006;

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Using the Box–Behnken Response Surface Method to Optimize the Preparation and Characterization of Lavender and Fennel Volatile oil β-cyclodextrin Form Inclusion Complex

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