cqvip:Objective: Tolerability and safety of 0.1% tacrolimus ointmentin treating nickel-induced allergic contact dermatitis (ACD)-were evaluated. Methods: Patients allergic to nickel applied nickel patches to each upper inner aspect of the arm for 4 to 8 hours daily. Tacrolimus was applied to patch site on one arm and vehicle to patch site on the other, twice daily. Physician’ s Global assessment, signs and symptoms of ACD, pruritus scores, and adverse events were evaluated. Results: After 8 weeks, dermatitis in 45% of patients was clear or almost clear (Physician’ s Global Assessment) with tacrolimus; and 1% with vehicle (P < .001). Significant results were achieved as early as day8. Tacrolimus was superior in ACD signs and symptoms improvement and pruritus reduction (P < .001). Adverse events were similar between treatments. Limitations: This model,involving one agent, may not be generalizable for other agents.Conclusions: Tacrolimus ointment 0.1% is well tolerated and significantly more effective than vehicle in treating chronically exposed, nickel-induced ACD.
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