cqvip:Objectives: To investigate whether age at onset of epilepsy, type of epilepsy , family history of psychosis, or family history of epilepsy affect the risk of schizophrenia or schizophrenia- like psychosis among patients with epilepsy. De sign: Comparison of population based data. Setting: Danish longitudinal register s. Subjects: The cohort comprised 2.27 million people. Main outcome measures: Ep ilepsy, psychosis, personal birth data. Results: We found an increased risk of s chizophrenia (relative risk 2.48, 95% confidence interval 2.20 to 2.80)- and schizophrenia- like psychosis (2.93, 2.69 to 3.20) in people with a history of epilepsy. The effect of epilepsy was the same in men and in women and increased with age. Family history of psychosis and a family history of epilepsy were sign ificant risk factors for schizophrenia and schizophrenia- like psychosis, and t he effect of epilepsy, both in cases and families, was greater among people with no family history of psychosis. In addition, the increased risk for schizophren ia or schizophrenia- like psychosis did not differ by type of epilepsy but incr eased with increasing number of admissions to hospital and, particularly, was si gnificantly greater for people first admitted for epilepsy at later ages. Conclu sions: There is a strong association between epilepsy and schizophrenia or schiz ophrenia- like psychosis. The two conditions may share common genetic or enviro nmental causes.
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