The purpose of this report is to characterize the clinical and electrophysiolo gical effects of extraocular muscle surgery in 15 patients with oculo-cutaneous albinism (OCA) and infantile nystagmus syndrome (INS). Our hypothesis is that s urgery on the extraocular muscles of patients with OCA and INS changes their nys tagmus and their visual function. Interventional, prospective, cohort, noncompar ative case series. All 15 patients had surgery on all four virgin horizontal rec ti; three for strabismus alone, three for nystagmus alone, five for an eccentric gaze null zone alone, and four for an eccentric gaze null zone plus strabismus. All patients have been followed for at least six months. All 15 patients had th e subjective outcome measure of pre-and postoperative binocular best optically corrected acuity (BBOCA). Objective outcome measures included anomalous head pos ture (AHP) in nine patients, eye movement recording measures of expanded nystagm us acuity function (NAFX) in 10 patients, null zone position (NUZP) and null zon e width (NUZW) in 10 patients, and foveation time (FOV) in nine patients. The re sults are summarized as follows; BBOCA increased 0.1 LogMar or greater in 14 of 15 patients. In those operated on for an AHP with or without associated strabism us the AHP improved significantly (P< . 01 for all)-.The NAFX, NUZP, NUZW, and FOV measured from eye movement recordings showed persistent, significant increas es in all patients (P < . 01 for all). This report adds to the evidence that sur gery on the extraocular muscles in patients with INS has independent neurologic and visual results.
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