This report describes the second known case of disseminated coccidioidomycosis mimicking mycosis fungoides since the original description more than 100 years ago. Coccidioidomycosis should be considered in persons from an endemic area presenting with nonhealing or suspicious skin lesions. Diagnosis is established by skin biopsy and silver staining showing granulomas and classic Coccidioides immitis spherules. Disseminated coccidioidomycosis most commonly involves the skin and can have a variety of cutaneous manifestations. The first description of a Coccidioides immitis infection in 1892 was initially diagnosed as mycosis fungoides. We present the second case of coccidioidomycosis masquerading as mycosis
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