报道了一种（E）-α，β-不饱和邻三氟乙酰氨基硝基烯烃及其衍生物的合成方法，并介绍了其在制备重要医药中间体中的应用。以邻硝基苯甲醛为起始原料，通过硝基还原、氨基取代和加成反应合成（E）-α，β-不饱和邻三氟乙酰氨基硝基烯烃类化合物，产物经过核磁共振1H NMR 和13C NMR确定其结构。%The synthesis of (E)-2,2,2-trifluoro-N-(2-(2-nitrovinyl)phenyl)acetamides and their applica-tions in the preparation of pharmaceutical intermediates were introduced. Using nitrobenzaldehyde as raw material, (E)-2,2,2-trifluoro-N-(2-(2-nitrovinyl)phenyl)acetamides were synthesized via reduction of nitro group,substitution of amino group and addition reaction. The product structures were characterized by 1H NMR and 13C NMR.
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