目的：探讨RBP4与非酒精性脂肪性肝病（NAFLD）肝脏病理学相关性，评估RBP4在诊断NAFLD中的价值。方法2010年7月至2015年12月病理检查证实的NAFLD患者61例，所有患者检测血清RBP4水平。依据肝细胞脂肪变性程度分为A组（脂肪变≤30%）、B组（脂肪变30%-75%）、C组（脂肪变≥75%）。依据炎症程度分为D组（G0-1）、E组（G2-3）。依据纤维化程度分组，F组（S0-1）、G组（s2-3）。比较各组的RBP4水平。结果随着A组、B组和C组肝细胞脂肪变程度加重，其RBP4水平也随之升高，三组间比较差异有统计学意义（P<0.001）。而随着D组、E组肝病理炎症水平的升高，两组间RBP4水平的差异无统计学意义（P>0.05）。F组、G组间RPB4水平也无统计学意义（P>0.05）。结论 RBP4与NAFLD患者肝组织脂肪变性的程度有显著相关性。RBP4越高，则NAFLD患者的肝脏脂肪变程度越严重， RBP4与肝脏炎症、纤维化无明显相关性。%ObjectiveTo investigate the value of RBP4 in the diagnosis of NAFLD and the correlation between RBP4 and liver pathology in NAFLD.Methods61 NAFLD patients confirmed by pathological examination were included in the study from July 2010 to December 2015,and all patients were tested for serum RBP4 levels. According to the degree of hepatic steatosis,61pationts were divided into A group(hepatic steatosis≤30%)、B group(30%-75%)and C group(≥75%). According to the degree of hepatic inflammation,61pationts were divided into D group (G0-1),E group(G2-3). According to the degree of fibrosis,61pationts were divided into group F(S0-1),group G(s2-3). Compare the RBP4 levels in each group.Results With the increase of hepatic steatosis in A,B and C goups,the levels of RBP4 increased,and the difference between the three groups was statistically significant(P<0.001). With the increase of hepatic inflammation in C and D group,there was no significant difference between the two groups(P>0.05). F group,G group RPB4 levels were not statistically significant(P>0.05).Conclusion There is a significant correlation between RBP4 and hepatic steatosis in NAFLD patients. The higher level of RBP4,the more severe hepotic steatosis in NAFLD patients.There is no significant correlation between RBP4 and hepotic inflammation、fibrosis.
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