Objective To investigate the relationship between serum zinc and copper levels and blood lipid in patients with type 2 diabetes mellitus complicated with coronary heart disease. Methods Thirty-five patients newly diagnosed with type 2 diabetes mellitus complicated with coronary heart disease(CHD)were selected as the observation group. And 60 healthy people were selected as the control group. The levels of serum zinc,copper,triglyceride,total cholesterol,low density lipoprotein and high density lipoprotein were determined. The relationship between serum zinc and copper levels,copper/zinc ratio and blood lipids were analyzed. Results Serum zinc level in the observation group was significantly lower than control group. But the levels of serum copper and copper / zinc ratio in the observation group were significantly higher than the control group. Serum zinc level was negatively correlated with triglyceride and total cholesterol levels in the observation group. While copper / zinc ratio was positively correlated with total cholesterol and triglyceride levels. No correlation existed between blood copper levels and three glycerol ester and total cholesterol. Conclusion The abnormality of serum zinc,serum copper and copper / zinc ratio may play an important role in the pathogenesis of dyslipidemia and type 2 diabetes mellitus complicated with coronary heart disease.%目的 探讨2型糖尿病合并冠心病患者血清锌、铜的水平与血脂的相关性.方法 选择初次诊断为2型糖尿病合并冠心病患者35例为观察组,另选择体检健康者60例为对照组.检测两组患者锌、铜、甘油三酯、总胆固醇、低密度脂蛋白、高密度脂蛋白水平.分析2型糖尿病合并冠心病患者血锌、铜水平及铜/锌比值与血脂的相关性.结果 观察组血锌水平明显低于对照组;但血铜水平及铜/锌比值明显高于对照组,观察组血锌与甘油三酯和总胆固醇水平呈负相关;铜/锌比值与甘油三酯和总胆固醇水平呈正相关;但血铜水平与甘油三酯和总胆固醇水平无相关性.结论 血锌和血铜水平及铜/锌比值的异常改变可能在血脂异常及2型糖尿病合并冠心病的发病中具有重要作用.
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