目的 探讨百令胶囊对急性加重期慢性阻塞性肺疾病(COPD)患者T淋巴细胞亚群及炎性因子的影响.方法 选择2013年5月至2016年10月急性加重期COPD患者130例,根据随机数字表法分为观察组与对照组,各65例,对照组患者采用常规西医综合治疗,观察组患者在常规治疗的基础上加用百令胶囊治疗,观察比较两组患者治疗前后的BODE指数、外周血T淋巴细胞亚群以及血清IL-β、IL-6、IL-8、TNF-α、IL-10、IL-2等炎性细胞因子水平的变化情况.结果 观察组患者治疗有效率(93.85％)明显高于对照组(76.92％),差异有统计学意义(χ2=7.46,P=0.01).治疗后两组患者BODE指数、MMRC评分均明显降低,BMI评分、FEV1％pred评分、6MWD评分均明显升高,差异均有统计学意义(P<0.05),且治疗后观察组患者BODE指数、MMRC评分明显低于对照组,BMI评分、FEV1％pred评分、6MWD评分明显高于对照组,差异均有统计学意义(P<0.05).治疗后两组患者的CD4+和CD4+/CD8+明显升高,CD8+明显降低,差异有统计学意义(P<0.05),且观察组患者的CD4+和CD4+/CD8+明显高于对照组,CD8+明显低于对照组,差异均有统计学意义(P<0.05).治疗后两组患者的IL-β、IL-6、IL-8、TNF-α水平明显降低,IL-2、IL-10水平明显升高,差异有统计学意义(P<0.05),且治疗后观察组患者IL-β、IL-6、IL-8、TNF-α水平明显低于对照组,IL-2、IL-10水平明显高于对照组,差异均有统计学意义(P<0.05).两组患者治疗期间不良反应差异无统计学意义(χ2=0.10,P=0.75).结论 百令胶囊治疗急性加重期COPD患者能够较好的改善患者的免疫功能,降低患者的炎症反应,改善患者的肺部症状,临床疗效较好,且安全性较高.%Objective To study the effect of bailing capsule on T lymphocyte subsets and inflammatory factors in patients with acute exacerbation of COPD. Methods From May 2013 to October 2016,130 patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) were divided into study group (65 cases) and control group (65 cases) according to the method of random number table. Patients in the control group were treated with conventional therapy,while patients in the study group were treated with bailing capsule combined with conventional treatment. The BODE index,peripheral blood T lymphocyte subsets,serum IL-β,IL-6,IL-8,IL-10 and IL-2 were measured and compared between two groups before and after treatment. Results The effective rate of the study group (93.85％) was significantly higher than that of the control group (76.92％),the difference was statistically significant (χ2=7.46,P=0.01). After treatment,BODE index,MMRC score were significantly decreased (P<0.05),and the BMI score,FEV1％ pred score,6MWD score were significantly increased in both groups of patients,and BMI score,FEV1％ pred score and 6MWD score in the study group were significantly higher in the study group than in the control group (P<0.05),and the BODE index and MMRC score of the study group were significantly lower than those of the control group (P<0.05). The CD4+and CD4+/CD8+ levels in the study group were significantly higher than those in the control group,and the levels of CD8+ were significantly lower than those in the control group,the difference were statistically significant (P<0.05). IL-6,IL-8 and TNF-α levels were significantly decreased and IL-2,IL-10 levels were significantly increased in both groups after treatment (P<0.05),and the levels of IL-6,IL-8 and TNF-α were significantly lower than those in the control group,and the levels of IL-2,IL-10 were significantly higher than those in the control group (P<0.05). There was no significant difference in adverse events between the two groups (χ2=0.10,P=0.75). Conclusion Bailing capsule can improve the immune function of patients with acute exacerbation of COPD,reduce the inflammatory response of patients,improve the patient's lung symptoms,the clinical efficacy is better and the security is higher.
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