Objective To explore the relevance of PRKAA2 gene polymorphism and atorvastatin in lipid-lowering to stabilize plaques in type 2 diabetes mellitus. Methods 203 cases with atherosclerosis in patients with type 2 diabetes were collected and checked neck ultrasound after 3 months of regular oral atorvastatin. They were divided into excellent group(116 cases) and failure group(87 cases) according to the prognosis of carotid plaques,detection PRKAA2 gene polymorphism was detected with the genetic sequencing technology. Results The PRKAA2 gene polymorphism (rs2796516 loci) G allele frequency in excellent group was significantly higher than the failure group(64.7％ vs 54.6％),GG genotype of excellent group was significantly higher than the failure group(39.7％ vs 33.3％),the difference was statistically significant(P<0.05).Genotype was no statistical difference. Conclusion There is certain correlation between PRKAA2 gene(rs2796516)site with atorvastatin calcium the effect of lipid stable plaques,then haploid type module(rs1124900 - rs2796516 - rs2746342 rs2051040 - rs2796498 - rs17848595 - rs1418442) of GATCAAT haploid type of atorvastatin calcium lipid stable plaques failure also has certain effect.%目的 探讨PRKAA2基因多态性与阿托伐他汀钙在2型糖尿病伴动脉粥样硬化患者降脂稳定斑块作用的相关性.方法 2型糖尿病伴动脉粥样硬化患者203例,常规口服阿托伐他汀3个月后复查颈部B超,按照颈动脉斑块预后结果分显效组(116例)及失效组(87例),应用基因测序技术检测PRKAA2基因多态性.结果 显效组PRKAA2基因多态性(rs2796516位点)G等位基因频率显著高于失效组(64.7％vs 54.6％),显效组GG基因型显著高于失效组(39.7％vs 33.3％),差异有统计学意义(P<0.05).余基因型比较差异无统计学意义.结论 PRKAA2基因(rs2796516)位点与阿托伐他汀钙降脂稳定斑块的效果存在一定的相关性,单倍型模块(rs1124900-rs2796516-rs2746342-rs2051040-rs2796498-rs17848595-rs1418442)的GATCAAT单倍型对阿托伐他汀钙降脂稳定斑块的失效也存在一定作用.
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