目的：探讨慢性阻塞性肺疾病（COPD）患者白细胞介素-6（IL-6）与可溶性白细胞介素-6（sIL-6R）受体的表达及意义。方法选取COPD患者60例，其中COPD急性期和缓解期患者各30例，分别采用ELISA检查血清IL-6与sIL-6R水平。结果 COPD急性期患者IL-6、sIL-6R水平显著高于缓解期患者，两组比较差异有统计学意义（P=0.041）。急性期COPD患者中，吸烟者IL-6、sIL-6R水平显著高于不吸烟者（P=0.040）。缓解期COPD患者中，吸烟者IL-6、sIL-6R水平显著高于不吸烟者（P=0.018）。血清IL-6、sIL-6R与用力肺活量（FVC）、1s用力呼气容积（FEV1）、FEV1%、FEV1/FVC呈显著负相关。结论 IL-6与sIL-6R水平在判断COPD发展、转归及预后上具有重要意义。%ObjectiveTo evaluate the clinical significance and expression of interleukin-6(IL-6)and soluble interleukin-6 receptor(sIL-6R) in patients with chronic obstructive pulmonary disease(COPD). Selected 60 patients with COPD as the research object. Used ELISA examination for serum IL-6 and sIL-6R level.ResultsThe levels of serum IL-6 and sIL-6R in patients with acute exacerbation of COPD were significantly higher than that in patients with remission of COPD,the difference was statistically significant(P=0.041). In acute exacerbation of COPD group,the levels of serum IL-6 and sIL-6R in smokers were significantly higher than that in non-smokers(P=0.040). In remission of COPD group,the level of serum IL-6 and sIL-6R in smokers were significantly higher than that in non-smokers(P=0.018). Serum IL - 6 and sIL-6R with FVC,FEV1,FEV1 and FEV1/ FVC % were significantly negative correlation.Conclusion The detection of serum IL - 6 and sIL-6R plays an important role in the development, outcome and prognosis of COPD.
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