Objective To observe effect of 24-hour urinary protein excretion with deproteinized calf blood protein extractives treatment in diabetic nephropathy patients.Methods Using single-blind method,118 diabetic nephropathy patients with high 24-hours urinary protein excretion randomly assigned into control group(80cases)and treatment group(38 cases);Two groups of patients had routine hypoglycemic treatment for two weeks;in treatment group,they were combined with the deproteinized calf blood extractives(800mg a day,intravenous), the control group were only treated with placebo of 0.9% saline 250ml,intravenous infusion;the patients were observed 24-hour of urinary protein excretion and adverse reactions before and after treatment.Results Before treatment,24-hour urinary protein was no significant difference in the two groups(Z=-1.100,P=0.270);After the treatment,24-hour urinary protein excretion in the treatment group was significantly lower(Z=-5.373,P=0.000),which was not changed significantly in the control group(Z=-0.375,P=0.707);two groups of patients had no adverse reactions during treatment.Conclusion Deproteinized calf blood extractives has the role of reducing 24-hour urinary protein in diabetic nephropathy patients,and it is safe and effective,worthy of clinical application.%目的 观察小牛血去蛋白提取物对糖尿病肾病患者24h尿蛋白定量的影响.方法 采用单盲法,将118例24h尿蛋白定量升高的糖尿病肾病患者随机分为观察组(38例)和对照组(80例),两组患者均常规降糖治疗,疗程均为2周,观察组加用注射用小牛血去蛋白提取物800mg静脉滴注,1次/d,对照组加安慰剂0.9%氯化钠注射液250ml,静脉滴注.观察两组患者治疗前后24h尿蛋白定量变化及不良反应.结果 两组治疗前24h尿蛋白定量比较差异无统计学意义(Z=-1.100,P=0.270);观察组治疗后24h尿蛋白定量明显降低,与对照组比较,差异有统计学意义(Z=-5.373,P=0.000);对照组治疗前、后24h尿蛋白定量比较,差异无统计学意义(Z=-0.375,P=0.707);两组患者在治疗期间均未出现不良反应.结论 小牛血去蛋白提取物具有降低糖尿病肾病患者24h尿蛋白定量的作用,安全有效,值得临床推广.
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