Objective To explore the relationship between the expression of Survivin,COX-2 and pathological grade of endometrial cancer and prognosis. Methods Immunohistochemistry was used to detect the expressions of Survivin and COX-2 in 62 cases of endometrial cancer. Analysis the relationship between the expression of Survivin,COX-2 and pathological grade of endometrial cancer and prognosis. Results The positive expression reates of Survivin and COX-2 were 82.3%and 61.3%. The difference of Survivin and COX-2 positive rates in FIGO stage and several pathological grades were significant(P<0.05). Survivin and COX-2 positive rates of Kps≤70 group were higher than Kps>70 group. The survival time of Survivin and COX-2 positive patients were longer than negative patients(P<0.05). Conclusion Survivin and COX-2 were over expression in endometrial cancer. They can be serve as negative prognosis factor.% 目的研究子宫内膜癌Survivin和COX-2的表达及与肿瘤级别和预后的关系.方法免疫组化法检测62例子宫内膜癌患者瘤组织Survivin和COX-2的表达,并对Survivin和COX-2的表达与子宫内膜癌的分级特征及患者生存时间进行统计分析.结果 Survivin和COX-2在子宫内膜癌中表达阳性率分别为82.3%,61.3%.子宫内膜癌的表达阳性率在不同FIGO分期及病理分级中的差异有统计学意义(P<0.05).Kps评分≤70分的患者子宫内膜癌的阳性率显著高于Kps评分>70分的患者(P<0.05).Survivin和COX-2表达阳性患者生存时间显著优于表达阴性的患者(P<0.05).结论 Survivin和COX-2在子宫内膜癌中高表达,可作为子宫内膜癌负性预后因子.
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