Objective To investigate the expression of insulin-like growth factor-I receptor(IGF-IR)and its relationship with tumor angiogenesis,cancer cell proliferation in invasive carcinoma of cervix. Methods Immunohistochemical method were adopted to examine expression of IGF-IR,microvascular density(MVD)labeled by CD34 protein and proliferation indexes of cancer cells labeled by Ki-67 protein in 93 cases with cervical carcinoma and 21 cases with normal cervical tissues. Results The protein expression rate of IGF-IR,MVD and Ki-67 in cervical carcinoma were significantly higher than in normal tissues. Over-expression of IGF-IR in cervical carcinoma was related to lymph node metastasis and depth of invasion. Conclusion In cervical carcinoma IGF-IR may play a important role in tumor angiogenesis,cancer cell proliferation.Detection expression of IGF-IR may be of value in further understanding in the biological behavior and predicting the progress of cervical carcinoma.%目的：探讨宫颈癌组织中胰岛素样生长因子-I受体（insulin-like growth factor-I receptor，IGF-IR）表达及其与肿瘤血管生成、癌细胞增殖的关系。方法采用免疫组织化学SP法检测93例宫颈癌和21例正常宫颈上皮组织中IGF-IR蛋白表达，并检测微血管密度（CD34标记）和癌细胞增殖指数（Ki-67标记）。结果宫颈癌组织中IGF-IR、微血管密度、Ki-67指数明显高于正常宫颈上皮组织（P<0.01），IGF-IR高表达与宫颈癌淋巴结转移和浸润深度有关，而与患者年龄、宫颈癌组织学类型和临床分期无明显相关性。结论 IGF-IR过度表达者，宫颈癌血管生成能力显著增强、癌细胞增殖活跃，检测宫颈癌中IGF-IR表达对进一步了解宫颈癌生物学行为和判断其预后有一定的价值。
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