Objective To explore the relationship between Alzheimer disease and polymorphisms of ApoE gene in Wenzhou area. Method 51 patients with Alzheimer disease (AD) and 54 normal controls in Wenzhou area were enrolled in this study. The ApoE gene polymorphism was analyzed with polymerase chain reaction ( PCR ). Results The patients with ApoEε4 had more psychological and behavioral disorders than normal controls( P ＜ 0. 05 ). Conclusion ApoEε4 is a risk gene for Alzheimer disease,and the patients with ApoEe4 should serve as early diagnosis and treatment evidence of the AD.%目的 探讨温州地区阿尔茨海默病(AD)与载脂蛋白E(ApoE)基因多态性的关系.方法 收集温州地区AD患者51例,另取正常对照者54例,采用聚合酶链反应法(PCR)进行ApoE基因分型.结果 ApoEε4基因分布频率AD组与对照组比较差异有统计学意义(P<0.05).结论 ApoEε4是AD的风险基因,可以作为AD患者早期诊断和治疗的依据.
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