Objective To analyze the incidence of mycoplasma infection in pregnant women with bacterial vaginosis and the sensitivity of mycoplasma antibiotics,in order to provide a theoretical reference for the rational use of drugs in clinical. Methods A total of 1680 pregnant women with bacterial vaginosis treated in our hospital from Mar. 2016 to Sep. 2017 were selected as the research objects,the vaginal secretions of patients were collected,then isolated and identified by mycoplasma isolation and culture kit,disk diffusion method for susceptibility testing,at last the incidence of mycoplasma infection,distribution and drug resistance were observed. Results The prevalence of mycoplasma in 1680 pregnant women with bacterial vaginosis was 55.12%(926/1680),the infection rate of Ureaplasma urealyticum(Uu)was 67.49%,the infection rate of Mycoplasma hominis(Mh) was 5.08%,the mixed infection rate of Uu+Mh was 27.43%;Uu,Mh,Uu+Mh all had higher sensitivity to josamycin,minocycline,doxycycline, and higher drug resistance to ciprofloxacin,respectively,Uu had higher sensitivity to azithromycin,roxithromycin,clarithromycin,but Mh,Uu+Mh less sensitive to them. Conclusion The incidence of mycoplasma infection in pregnant women with bacterial vaginosis is high,josamycin,minocycline and doxycycline are highly sensitive to mycoplasma infection and can be widely used clinically. In addition,for different types of mycoplasma infection, clinicians should choose antibiotics reasonably according to drug sensitivity test results.%目的 分析细菌性阴道炎孕妇合并支原体感染的发生率及对支原体抗菌药物的敏感性,以指导临床合理用药.方法 选取2016年3月至2017年9月收治的1680例细菌性阴道炎孕妇为观察对象,采集患者阴道分泌物,用支原体分离培养药敏试剂盒进行分离鉴定,以纸片扩散法进行药敏试验,观察患者支原体感染发生率、分布及耐药性.结果 1680例细菌性阴道炎孕妇患者支原体感染发生率为55.12% (926/1680),其中解脲支原体(Uu)感染率为67.49%、人型支原体(Mh)感染率为5.08%、Uu+Mh混合感染率为27.43%;Uu、Mh对交沙霉素、美满霉素、强力霉素均有较高的敏感性,对环丙沙星均具有较高的耐药性,Uu对阿奇霉素、罗红霉素、克拉霉素具有较高的敏感性,但Mh对其敏感性较差.结论 细菌性阴道炎孕妇合并支原体感染的发生率较高,交沙霉素、美满霉素、强力霉素对支原体感染具有较高的敏感性,可在临床上推广应用.另外,对于不同类型的支原体感染,临床医师应根据药物敏试验结果合理选用抗生素进行治疗.
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