目的：了解糖尿病足患者截肢率及截肢影响因素。方法：收集2007年1月至2012年3月住院的糖尿病足患者，比较截肢与非截肢组的临床特征，采用Logistic回归分析截肢的主要影响因素。结果：570例糖尿病足患者中有88例（15.4％）接受截肢手术，截肢组足病病程、血白细胞及中性粒细胞比例、饮酒率、多发溃疡率、创面混合感染率高于非截肢组（ P＜0.05）。白蛋白、血红蛋白、HDL－C低于非截肢组（ P＜0.05）。大截肢组创面革兰氏阴性菌比例、多发溃疡率、血白细胞及中性粒细胞比例高于小截肢组，血白蛋白低于小截肢组（ P＜0.05）。Logistic回归分析发现足背动脉、饮酒、贫血、血白细胞是截肢的危险因素，HDL －C是截肢的保护因素。结论：足背动脉搏动差、饮酒、贫血、感染、低HDL－C是糖尿病足患者截肢的主要影响因素。%Objective ] To evaluate the incidence of amputation among patients with diabetic foot ulcer and risk factors for am-putations .[Method] Inpatients with diabetic foot ulcer were recruited from January 2007 to March 2012 .Clinical character was compared between amputation group and non-amputation group and the critical factors contributing to amputations were ana-lyzed with logistic regression .[Result] 88 patient (15.4% ) underwent amputation .Higher foot ulcer duration, white blood cell counts, neutrophils percentage, rates of alcohol consumption, multiple ulcer and mixed infections and lower plasma albu-min, blood hemoglobin, high-density lipoprotein-cholesterol were found in amputation group compared with the non-ampu-tation group ( P<0.05 ) .The major amputation group had higher white blood cell counts, neutrophils percentage, proportion of Gram-negtive bacteria, rate of multiple ulcer and lower plasma albumin than minor amputation group ( P<0.05 ) .Upon lo-gistic regression analysis, dorsal artery of foot, alcohol consumption, anaemia, white blood cell counts were independent risk factor of amputation, HDL-C was independent protective factor of amputation .[Conclusion] The critical influencing factor for amputation were weakness or absent pulsation of dorsal artery of foot, alcohol consumption, anaemia, infection, low HDL-C.
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