Objective To investigate the relationship between cardio- ankle vascular indexes (CAVIs) and plasma B- type natriuretic peptide (BNP) levels in hypertensive patients. Methods Plasma BNP level, biochemical index, and CAVI were measured in 84 hypertensive patients (68±7)years;and echocardiography was also performed to evaluate left ventricular hypertrophy and function. Results Plasma BNP levels were significantly correlated with CAVI, age and course of disease (r=0.281, 0.269 and - 0.241, P<0.05). Multiple linear regression analysis revealed that CAVI was an independent determinant of BNP (β=0.282, P<0.05). In addition, CAVI was correlated with age, body mass index, and use of βblockers(r=0.359,- 0.234 and - 0.266, P<0.01 or 0.05); and regression analysis revealed that age was an independent determinant of CAVI (β=0.380, P<0.01). Conclusion The present study reveals that increased CAVI is an independent risk factor of elevated plas-ma BNP in hypertensive patients.%目的：研究高血压病患者心踝指数（CAVI）与血浆B型钠尿肽（BNP）水平的相关性。方法选择门诊高血压病患者84例，平均年龄（68±7）岁。测定血浆BNP水平、生化指标和CAVI，同时通过超声心动图评估左心室肥厚和心脏舒缩功能。结果BNP与CAVI、年龄、高血压病程相关（r=0.281、0.269、-0.241，均P＜0.05），多元线性回归分析显示CAVI为BNP的独立影响因素（β=0.282，P＜0.05）；另外，CAVI还与年龄、BMI、是否使用β受体阻滞剂相关（r=0.359、-0.234、-0.266，P＜0.01或0.05），多元线性回归分析显示年龄为CAVI的独立影响因素（β=0.380，P＜0.01）。结论高血压病患者CAVI增高是BNP水平增高的独立危险因素，随着动脉硬化程度的增高，心脏后负荷增大，可能加重心脏损害。
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