首页> 中文期刊> 《动物学研究》 >Preliminary study on fine structures of subcortical nuclei in rhesus monkeys by ex vivo 9.4 T MRI

Preliminary study on fine structures of subcortical nuclei in rhesus monkeys by ex vivo 9.4 T MRI

         

摘要

DEAR EDITOR,Changes in fine structures of the brain over a life span can have robust effects on neural activity and brain function,which both play crucial roles in neurodegenerative diseases.Clinically,however,low-resolution MRI only provides limited information about fine brain structures.Here,using highresolution 9.4 T MRI,we established a set of structural images and explored the fine structures of the claustrum,hippocampus,amygdala complex,and subregions of the amygdala complex(BLA,including lateral,basal,and accessory basal subnuclei)in rhesus macaque(Macaca mulatta)brains.Based on these high-resolution images,we were able to discriminate the subregional boundaries accurately and,at the same time,obtain the volume of each brain nuclei.Thus,advanced high-resolution 9.4 T MRI not only provides a new strategy for early diagnosis of neurodegenerative diseases,but also provides the ability to observe fine structural changes in the brain across a life span.

著录项

  • 来源
    《动物学研究》 |2020年第2期|199-202|共4页
  • 作者单位

    Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences&Yunnan Province;

    Kunming Institute of Zoology;

    Chinese Academy of Sciences;

    Kunming;

    Yunnan 650223;

    China;

    High Magnetic Field Laboratory;

    Hefei Institutes of Physical Science;

    Chinese Academy of Sciences;

    Hefei;

    Anhui 230031;

    China;

    Kunming College of Life Science;

    University of Chinese Academy of Sciences;

    Kunming;

    Yunnan 650223;

    China;

    CAS Center for Excellence in Animal Evolution and Genetics;

    Chinese Academy of Sciences;

    Kunming;

    Yunnan 650223;

    China;

    CAS Center for Excellence in Brain Science and Intelligence Technology;

    Chinese Academy of Sciences;

    Hefei;

    Anhui 230031;

    China;

    Kunming Primate Research Center of the Chinese Academy of Sciences;

    Kunming Institute of Zoology;

    Chinese Academy of Sciences;

    Kunming;

    Yunnan 650223;

    China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 诊断学;
  • 关键词

    diagnosis; Clinical; diseases;

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