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CurrentAdvances in Polymer-Based Nanotheranosticsfor Cancer Treatment and Diagnosis

机译:当前聚合物纳米化学的研究进展用于癌症的治疗和诊断

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摘要

Nanotheranostics is a relatively new, fast-growing field that combines the advantages of treatment and diagnosis via a single nanoscale carrier. The ability to bundle both therapeutic and diagnostic capabilities into one package offers exciting prospects for the development of novel nanomedicine. Nanotheranostics can deliver treatment while simultaneously monitoring therapy response in real-time, thereby decreasing the potential of over- or under-dosing patients. Polymer-based nanomaterials, in particular, have been used extensively as carriers for both therapeutic and bioimaging agents and thus hold great promise for the construction of multifunctional theranostic formulations. Herein, we review recent advances in polymer-based systems for nanotheranostics, with a particular focus on their applications in cancer research. We summarize the use of polymer nanomaterials for drug delivery, gene delivery, and photodynamic therapy, combined with imaging agents for magnetic resonance imaging, radionuclide imaging, and fluorescence imaging.
机译:纳米治疗学是一个相对较新的,快速发展的领域,它通过单个纳米级载体将治疗和诊断的优势结合在一起。将治疗和诊断功能捆绑在一起的能力为开发新型纳米医学提供了令人兴奋的前景。 Nanotheranostics可以在提供治疗的同时,实时监控治疗反应,从而降低了患者用药过量或不足的可能性。尤其是,基于聚合物的纳米材料已被广泛用作治疗剂和生物成像剂的载体,因此对于构建多功能治疗剂配方具有广阔的前景。本文中,我们回顾了用于纳米热固性聚合物的聚合物系统的最新进展,特别关注它们在癌症研究中的应用。我们总结了聚合物纳米材料在药物递送,基因递送和光动力疗法中的应用,并与用于磁共振成像,放射性核素成像和荧光成像的成像剂相结合。

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