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首页> 美国卫生研究院文献>Advances in Pharmacological Sciences >Beneficial Effect of Cissus quadrangularis Linn. on Osteopenia Associated with Streptozotocin-Induced Type 1 Diabetes Mellitus in Male Wistar Rats
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Beneficial Effect of Cissus quadrangularis Linn. on Osteopenia Associated with Streptozotocin-Induced Type 1 Diabetes Mellitus in Male Wistar Rats

机译：Cissus quadrangularis Linn的有益作用。 Wistar大鼠链脲佐菌素与链脲佐菌素诱导的1型糖尿病的关系

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摘要

Petroleum ether fraction of Cissus quadrangularis (PECQ) impact on the development of osteopenia in type 1 diabetic rat model has been evaluated. Diabetic rats were treated orally with two doses of PECQ. Another group of diabetic rats were treated with subcutaneous injection of synthetic human insulin. The cortical and trabecular bone thickness and bone strength were significantly decreased in diabetic rats. Treatment with two doses of PECQ significantly prevented these changes in diabetic rats. However, PECQ treatment (two doses) did not alter the glycemic levels in these diabetic rats. Increased levels of serum alkaline phosphatase (ALP), tartrate-resistant acid phosphatase (TRAP), and hydroxyproline were noted in diabetic rats when compared to normal control rats. The two doses of PECQ treatment further improved the serum ALP levels and significantly decreased the serum levels of TRAP and hydroxyproline. The effects of PECQ treatment on histological, biomechanical, and biochemical parameters are comparable to those of insulin. Since PECQ improves the bone health in hyperglycemic conditions by enhancing the cortical and trabecular bone growth and altering the circulating bone markers, it could be used as an effective therapy against diabetes-associated bone disorders.
机译：已经评估了四边形中的石油醚分数（PECQ）对1型糖尿病大鼠模型中骨质减少的影响。糖尿病大鼠口服两次PECQ。另一组糖尿病大鼠经皮下注射合成人胰岛素治疗。糖尿病大鼠的皮质和小梁骨厚度和骨强度显着降低。用两剂PECQ进行治疗可显着预防糖尿病大鼠的这些变化。但是，PECQ治疗（两剂）并未改变这些糖尿病大鼠的血糖水平。与正常对照组相比，糖尿病大鼠的血清碱性磷酸酶（ALP），抗酒石酸酸性磷酸酶（TRAP）和羟脯氨酸水平升高。两剂PECQ治疗可进一步提高血清ALP水平，并显着降低TRAP和羟脯氨酸的血清水平。 PECQ治疗对组织学，生物力学和生化参数的影响与胰岛素相当。由于PECQ通过增强皮质和小梁的骨生长并改变循环中的骨标志物来改善高血糖情况下的骨骼健康，因此它可以用作抗糖尿病相关骨疾病的有效疗法。

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