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首页> 美国卫生研究院文献>American Journal of Public Hygiene >A comparison of the intradermal and subcutaneous routes of influenza vaccination with A/New Jersey/76 (swine flu) and A/Victoria/75: report of a study and review of the literature.
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A comparison of the intradermal and subcutaneous routes of influenza vaccination with A/New Jersey/76 (swine flu) and A/Victoria/75: report of a study and review of the literature.

机译：用A / New Jersey / 76（猪流感）和A / Victoria / 75进行流感疫苗接种的皮内和皮下途径比较：一项研究报告并复习文献。

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摘要

A trail of influenza vaccination, with use of bivalent split virus vaccine (A/New Jersey/76 and A/Victoria/75), was conducted to compare the immunogenicity and reactions when vaccine was given by the subcutaneous and intradermal routes. Volunteers 18 to 24 years old were randomized into equal groups, one group receiving 0.1 ml of vaccine intradermally and the other receiving 0.5 ml subcutaneously. For the A/Victoria vaccine, the immunogenicity of the intradermal route seemed superior; for A/New Jersey vaccine, the routes were equivalent. Adverse reactions were minimal and equivalent for both groups. In times of vaccine shortage, the intradermal route is considered to stretch vaccine supplies. Field trials of new influenza vaccines should include evaluation of the immunogenicity of and adverse reactions caused by the same vaccine given by different routes in varied dosages.
机译：使用二价分裂病毒疫苗（A / New Jersey / 76和A / Victoria / 75）进行了流感疫苗接种试验，以比较通过皮下和皮内途径接种疫苗时的免疫原性和反应。将18至24岁的志愿者随机分为两组，一组皮内接受0.1毫升疫苗，另一组皮下接受0.5毫升疫苗。对于A /维多利亚疫苗，皮内途径的免疫原性似乎更好。对于A /新泽西州疫苗，路线是相同的。两组的不良反应极少，且等效。在疫苗短缺的时候，皮内途径被认为可以延长疫苗供应。新流感疫苗的现场试验应包括评估不同剂量不同途径给予同一疫苗的免疫原性和不良反应。

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