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Empirical determination of breed-of-origin of alleles in three-breed cross pigs

机译:三品种杂交猪等位基因起源品种的经验确定

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摘要

BackgroundAlthough breeding programs for pigs and poultry aim at improving crossbred performance, they mainly use training populations that consist of purebred animals. For some traits, e.g. residual feed intake, the genetic correlation between purebred and crossbred performance is low and thus including crossbred animals in the training population is required. With crossbred animals, the effects of single nucleotide polymorphisms (SNPs) may be breed-specific because linkage disequilibrium patterns between a SNP and a quantitative trait locus (QTL), and allele frequencies and allele substitution effects of a QTL may differ between breeds. To estimate the breed-specific effects of alleles in a crossbred population, the breed-of-origin of alleles in crossbred animals must be known. This study was aimed at investigating the performance of an approach that assigns breed-of-origin of alleles in real data of three-breed cross pigs. Genotypic data were available for 14,187 purebred, 1354 F1, and 1723 three-breed cross pigs.
机译:背景尽管猪和家禽的育种计划旨在提高杂交性能,但它们主要使用由纯种动物组成的训练种群。对于某些特征,例如如果采食剩余饲料,则纯种和杂交性能之间的遗传相关性较低,因此需要将杂交动物包括在训练种群中。对于杂种动物,单核苷酸多态性(SNP)的影响可能是特定于品种的,因为SNP和定量性状基因座(QTL)之间的连锁不平衡模式,以及QTL的等位基因频率和等位基因替代效应在不同品种之间可能有所不同。为了估计等位基因在杂交种群中的特定品种效应,必须知道杂交动物中等位基因的起源品种。这项研究旨在调查在三头杂交猪的真实数据中分配等位基因起源品种的方法的性能。基因型数据可用于14,187头纯种,1354 F1和1723三头杂交猪。

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