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首页> 美国卫生研究院文献>Annals of Tropical Medicine and Parasitology >Prevalence of soil-transmitted helminths after mass albendazole administration in an indigenous community of the Manu jungle in Peru
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Prevalence of soil-transmitted helminths after mass albendazole administration in an indigenous community of the Manu jungle in Peru

机译：在秘鲁阿努丛林的一个土著社区大规模施用阿苯达唑后土壤传播的蠕虫的患病率

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Few data are available on the epidemiology of soil-transmitted helminths (STHs) in indigenous populations of the Peruvian Amazon. While albendazole is being increasingly used in deworming campaigns, few data exist on the impact of mass drug administration in isolated populations. We studied the prevalence of STHs, anemia, and malnutrition in a Matsigenka ethnic group from the Peruvian Amazon. Participants had received two doses of albendazole on consecutive days, 3 months before and again 2 weeks before data collection. Overall, 290 subjects were included. Most were female (53.7%) and 63.9% were ≤19 years old. Half of the participants had helminth infections. Trichiuris (30.2%), hookworm (19.1%), Ascaris (17.7%), and Strongyloides (5.6%) were the most common helminths. Other helminth ova included Capillaria hepatica and Fasciola-like eggs. Subjects of 5–19 years (51.8 %) and 20–35 years (68.6 %) old had helminths more often than those under 5 years (38%) and older than 35 years (41.5%) (P  =  0.02). Anemia was detected in 41% of children and this was more common in children under 5 years that in those of 5–19 years [odd ratio (OR)  =  5.68; 95% CI: 2.71–11.88]. Overall, 72.1% of children were malnourished. Stunting was common in children (70.7%), but wasting was not (2.9%). Despite repeated albendazole administration, this population continued to have a high prevalence of STHs, anemia, and malnutrition. In addition, we detected unusual organisms and organisms that do not respond to albendazole. Further studies are needed to assess the rationale and efficacy of mass chemotherapy for STHs in the Amazon.
机译：秘鲁亚马逊土著人口中土壤传播蠕虫（STHs）的流行病学数据很少。虽然阿苯达唑越来越多地用于驱虫运动，但很少有关于大规模药物管理对孤立人群的影响的数据。我们研究了秘鲁亚马逊地区Matsigenka族人群中STH，贫血和营养不良的患病率。参与者在连续三天（数据收集之前3个月之前和之后2周）连续接受了两剂阿苯达唑。总体上，包括290名受试者。大部分为女性（53.7％），63.9％≤19岁。一半的参与者患有蠕虫感染。蠕虫（30.2％），钩虫（19.1％），A虫（17.7％）和铁线虫（5.6％）是最常见的蠕虫。其他蠕虫卵包括肝毛细血管和类似Fasciola的卵。 5-19岁（51.8％）和20-35岁（68.6％）的受试者患蠕虫病的频率比5岁以下（38％）和35岁以上（41.5％）的受试者高（P = 0.02）。在41％的儿童中发现了贫血，这在5岁以下的儿童中比5-19岁的儿童更普遍[几率（OR）= 5.68； 95％CI：2.71–11.88]。总体而言，有72.1％的儿童营养不良。儿童发育迟缓很普遍（70.7％），而消瘦并不常见（2.9％）。尽管反复使用阿苯达唑，但该人群的STH，贫血和营养不良的患病率仍很高。此外，我们发现了不常见的生物和对阿苯达唑不响应的生物。需要进行进一步的研究，以评估亚马逊地区大规模化学疗法治疗STH的原理和功效。

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