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Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise

机译:绿茶多酚表没食子儿茶素3-没食子酸酯在关节炎中的应用:进展和希望

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摘要

Green tea's active ingredient, epigallocatechin 3-gallate (EGCG), has gained significant attention among scientists and has been one of the leading plant-derived molecules studied for its potential health benefits. In the present review I summarize the findings from some of the most significant preclinical studies with EGCG in arthritic diseases. The review also addresses the limitations of the dose, pharmacokinetics, and bioavailability of EGCG in experimental animals and findings related to the EGCG-drug interaction. Although these findings provide scientific evidence of the anti-rheumatic activity of EGCG, further preclinical studies are warranted before phase clinical trials could be initiated with confidence for patients with joint diseases.
机译:绿茶的活性成分表没食子儿茶素3-没食子酸酯(EGCG)在科学家中引起了极大的关注,并因其潜在的健康益处而成为研究的主要植物来源分子之一。在本综述中,我总结了一些最重要的关节炎疾病前期EGCG临床前研究的发现。该评价还解决了实验动物中EGCG的剂量,药代动力学和生物利用度的局限性以及与EGCG-药物相互作用有关的发现。尽管这些发现为EGCG的抗风湿活性提供了科学依据,但仍需进行进一步的临床前研究,才能对关节疾病患者充满信心地开展临床试验。

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