Inflammasome lights up in systemic sclerosis

机译：炎性体在全身性硬化症中亮起

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Systemic sclerosis (SSc) is a pro-fibrotic condition with a poorly understood aetiology. Evidence presented by Artlett et al. in this issue suggests that the microRNA miR-155 is key, with its involvement dependent on the NLRP3 inflammasome. This links epigenetic events with inflammasome signalling in SSc and opens the door to new therapeutic strategies for the treatment of SSc.

机译：系统性硬化症（SSc）是一种肝纤维化疾病，病因学知之甚少。 Artlett等人提供的证据。本期文章表明，microRNA miR-155是关键，其参与依赖于NLRP3炎性小体。这将表观遗传事件与SSc中的炎症小体信号联系起来，并为SSc的新治疗策略打开了大门。

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期刊名称 Arthritis Research
作者
John Henderson; Steven O’Reilly;
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作者单位

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年(卷),期 2017(19),-1
年度 2017
页码 205
总页数 2
原文格式 PDF
正文语种
中图分类外科学;
关键词
Sclerosis Fibrosis Inflammasome microRNA Epigenetics Interleukin-1 Caspase-1 MCC950;

机译：硬化;纤维化;炎症小体;microRNA;表观遗传学;白介素-1;胱天蛋白酶-1;MCC950;

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专利

1. Targeting TLRs and the inflammasome in systemic sclerosis [J] . Henderson John, Bhattacharyya Swati, Varga John, Pharmacology and Therapeutics: The Journal of the International Encyclopedia of Pharmacology and Therapeutics . 2018,第期

机译：靶向TLRS和系统性硬化症中的炎症
2. Mir-155 is overexpressed in systemic sclerosis fibroblasts and is required for NLRP3 inflammasome-mediated collagen synthesis during fibrosis [J] . Carol M. Artlett, Sihem Sassi-Gaha, Jennifer L. Hope, Arthritis research & therapy. . 2017,第1期

机译：Mir-155在系统性硬化成纤维细胞中过表达，是纤维化过程中NLRP3炎性体介导的胶原合成所必需的
3. The inflammasome activating caspase 1 mediates fibrosis and myofibroblast differentiation in systemic sclerosis [J] . Carol M. Artlett, Sihem Sassi-Gaha, Judy L. Rieger, Arthritis & Rheumatism . 2011,第11期

机译：炎性体激活胱天蛋白酶1介导系统性硬化中的纤维化和成纤维细胞分化。
4. Iloprost Treatment in Systemic Sclerosis – Effects on Autonomic Nervous System Assessed through Heart Rate Variability Parameters [C] . Elena Esmeralda Saramet, Doina-Clementina Cojocaru, Sorin Ungurianu, E-Health and Bioengineering Conference . 2020

机译：ILOPROST治疗在全身硬化 - 通过心率变异参数评估自主神经系统的影响
5. Multi-Omic Characterization of Macrophage Activation States in Systemic Sclerosis [D] . Toledo, Diana M. 2019

机译：巨噬细胞激活态在全身硬化症中的多环境特征
6. Mir-155 is overexpressed in systemic sclerosis fibroblasts and is required for NLRP3 inflammasome-mediated collagen synthesis during fibrosis [O] . Carol M. Artlett, Sihem Sassi-Gaha, Jennifer L. Hope, 2017

机译：Mir-155在全身性硬化症成纤维细胞中过表达是纤维化过程中NLRP3炎性体介导的胶原合成所必需的
7. Inflammasome lights up in systemic sclerosis [O] . Henderson John, OReilly Steven 2017

机译：炎性体在全身性硬化症中亮起

Inflammasome lights up in systemic sclerosis

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