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首页> 美国卫生研究院文献>British Heart Journal >Functional status of patients with large ventricular septal defect and pulmonary vascular disease 6 to 16 years after surgical closure of their defect in childhood.
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Functional status of patients with large ventricular septal defect and pulmonary vascular disease 6 to 16 years after surgical closure of their defect in childhood.

机译：大面积室间隔缺损和肺血管疾病患者的手术状态在儿童期手术关闭后6至16年处于正常状态。

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摘要

We have reviewed 27 patients now 6 to 16 years after closure of a ventricular septal defect at 3 to 12 years of age associated with pulmonary hypertension with a view to assessing their quality of life, respiratory function, and exercise performance. All the patients led normal unrestricted lives. Their subjective lack of symptoms was, in general, confirmed by the results obtained from assessment of lung function tests and two-stage exercise testing in 19 volunteers. Abnormal ventilation in relation to work load was noted in 5 patients and a slightly low exercise cardiac output in 6. Although the patients led normal lives and had a satisfactory response to exercise, measurement of pulmonary artery pressure showed striking pulmonary hypertension on effort. Despite the satisfactory progress of these patients their more long-term future must be one of conjecture and their residual pulmonary hypertension, indicative of residual pulmonary obstruction, must lend weight to arguments for earlier closure of ventricular septal defect before 1 to 2 years of age when changes in the pulmonary vascular bed may be reversed after closure of the defect.
机译：我们评估了3到12岁与肺动脉高压相关的室间隔缺损闭合后6至16年的27例患者，以评估其生活质量，呼吸功能和运动表现。所有患者过着正常无限制的生活。通常，他们的主观症状没有得到证实，这是通过对19名志愿者进行的肺功能测试和两阶段运动测试评估得出的。 5名患者发现与工作负荷有关的通气异常，6名患者的运动心输出量略低。尽管患者生活正常且对运动的反应令人满意，但肺动脉压的测量显示，在努力时出现肺动脉高压。尽管这些患者取得了令人满意的进展，但他们的更长期未来仍是推测之一，其残余肺动脉高压（表示残余肺阻塞）必须为在1至2岁之前更早闭合室间隔缺损提供依据。缺损闭合后，肺血管床的变化可能会逆转。

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