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首页> 美国卫生研究院文献>British Journal of Industrial Medicine >Experimental asbestosis: an investigation of functional and pathological disturbances. II. Results for chrysolite and amosite exposure
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Experimental asbestosis: an investigation of functional and pathological disturbances. II. Results for chrysolite and amosite exposure

机译：实验性石棉沉着症：功能和病理障碍的调查。二。绿泥石和铁石棉接触的结果

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ABSTRACT Long-term studies of respiratory function and lung morphology were carried out on control groups of guinea pigs and matched groups exposed by inhalation to asbestos dust. Animals were exposed to aerosols of chrysotile or amosite asbestos containing large numbers of short fibres, for either 9 or 18 days. Resistance and dynamic compliance of the guinea pig respiratory system were measured non-destructively, while the point counting technique was applied to the histological preparations. Under these exposure conditions the extent of pathological and functional changes were not related to differences in duration of exposure. Such changes were more marked, however, in animals exposed at eight rather than three months of age. The measurement of dynamic compliance provided the most sensitive assessment of the functional disturbances, which were more extensive following chrysotile exposure. Progressive peribronchiolar fibrosis developed about 40 weeks after chrysotile exposure at eight months of age, but not until about 70 weeks for animals exposed when three months old. No fibrotic reaction was seen during the 70 weeks of the amosite experiments. The relationships between pathological and functional changes throughout these experiments are discussed, and explanations for the apparent differences in fibrogenicity between chrysotile and amosite are suggested. Early detection of asbestosis may be aided by use of lung function tests known to be sensitive to small airways disease.
机译：摘要对豚鼠对照组和吸入石棉粉尘的配对组进行了呼吸功能和肺形态的长期研究。使动物暴露于含有大量短纤维的温石棉或铁石棉气雾剂中，持续9天或18天。无损测量豚鼠呼吸系统的抵抗力和动态顺应性，同时将点计数技术应用于组织学制备。在这些暴露条件下，病理和功能变化的程度与暴露持续时间的差异无关。然而，这种变化在暴露于八个月而不是三个月大的动物中更为明显。动态顺应性的测量提供了对功能障碍的最敏感评估，在温石棉暴露后，这些功能性干扰更为广泛。温石棉在八个月大的暴露后约40周发展为进展性支气管周纤维化，但直到三个月大的动物暴露于约70周才发展。在铁石棉试验的70周内未见纤维化反应。讨论了贯穿这些实验的病理学和功能变化之间的关系，并提出了温石棉和铁石棉之间纤维化性表观差异的解释。可以通过使用已知对小气道疾病敏感的肺功能检查来辅助早期发现石棉沉睡。

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