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首页> 美国卫生研究院文献>British Journal of Industrial Medicine >Biomonitoring results and cytogenetic markers among harbour workers with potential exposure to river silt aerosols
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Biomonitoring results and cytogenetic markers among harbour workers with potential exposure to river silt aerosols

机译：港口工人可能接触河粉尘气溶胶的生物监测结果和细胞遗传标记

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>Background: Workers on dredgers and lighters on rivers are potentially exposed to a variety of substances. >Aims: To determine the internal load of heavy metals and arsenic as well as levels of cytogenetic markers in workers exposed to river silt aerosols. >Methods: One hundred exposed workers were examined up to eight times within three years. Additionally, 100 control workers were studied once. Blood samples were analysed for lead, mercury, and cadmium. Additionally, micronuclei frequency and sister chromatid exchange (SCE) rates were determined. Urinary samples were analysed for cadmium, mercury, nickel, chromium, and arsenic. Information on potential confounders, such as smoking habits and consumption of fish were assessed. >Results: Apart from some increased concentrations of mercury in blood (maximum 14.6 µg/l) and arsenic in urine (maximum 356.5 µg/l) all measurements were within reference values. None of the exposure and effect markers were found to be significantly increased in exposed workers compared to non-exposed controls. In multiple linear regression models, mercury levels in blood as well as the concentration of arsenic in urine were strongly related to fish consumption. Cadmium levels in blood as well as urinary cadmium concentrations were strongly related to smoking habits. After adjusting for smoking habits, SCE rates were associated with cadmium levels in blood. >Conclusion: Increased exposure levels or enhanced levels of cytogenetic markers were not found in workers exposed to river silt aerosols. However, cadmium exposure in blood was related to SCE frequency.
机译：>背景：挖泥机的工人和河上的打火机的工人可能接触各种物质。 >目的：确定接触河粉尘气溶胶的工人的重金属和砷的内部负荷以及细胞遗传标志物的水平。 >方法：三年内对一百名暴露的工人进行了八次检查。另外，对100名控制人员进行了一次研究。分析血液样本中的铅，汞和镉。此外，确定了微核频率和姐妹染色单体交换（SCE）率。分析了尿液样本中的镉，汞，镍，铬和砷。评估了有关潜在混杂因素的信息，例如吸烟习惯和鱼类食用。 >结果：除了血液中汞的含量（最高14.6 µg / l）和砷中的砷（最大356.5 µg / l）有所增加外，所有测量值均在参考值之内。与未暴露的对照组相比，未发现暴露的工人的暴露和效果指标显着增加。在多个线性回归模型中，血液中的汞含量以及尿液中的砷浓度与鱼的摄入量密切相关。血液中的镉水平以及尿中的镉浓度与吸烟习惯密切相关。调整吸烟习惯后，SCE率与血液中的镉水平相关。 >结论：在接触河粉尘气溶胶的工人中未发现暴露水平升高或细胞遗传标志物水平升高。但是，血液中的镉暴露与SCE频率有关。

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