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首页> 美国卫生研究院文献>British Journal of Pharmacology and Chemotherapy >Depression of the vasomotor centre by mecamylamine independent of its ganglion-blocking activity
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Depression of the vasomotor centre by mecamylamine independent of its ganglion-blocking activity

机译：甲氧明胺抑制血管舒缩中心独立于其神经节阻滞活性

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摘要

Mecamylamine depressed the vasomotor centre independently of its ganglion-blocking action. The central action was elicited by small amounts of the drug when it was confined to the central nervous system of dogs and cats anaesthetized with pentobarbital sodium and of spinal cats. The spinal site of action was shown by the inhibition of vasomotor responses due to spinal compression in cats, when mecamylamine was introduced intrathecally in a dose too small to block autonomic ganglia. The supraspinal site of action was shown by intravertebral arterial injection of mecamylamine into cats, which caused hypotension and selectively blocked the electrically evoked pressor responses from the medulla without affecting the “nicotinic” ganglionic responses to acetylcholine. Injection of mecamylamine into the cerebral ventricles of dogs produced hypotension, and the reflex vasomotor responses to stimulation of afferent fibres in the vagus nerves and to occlusion of the common carotid arteries were inhibited without any change in the response of the nictitating membrane to preganglionic nervous stimulation.
机译：美加明胺可独立于其神经节阻滞作用而抑制血管舒缩中枢。当将这种药物限制在用戊巴比妥钠麻醉的猫狗和脊柱猫的中枢神经系统中时，其起中枢作用是由少量药物引起的。当鞘内注射美加明胺的剂量太小而不能阻断植物神经节时，通过抑制猫的脊柱压缩引起的血管舒缩反应可以显示出脊柱的作用部位。椎间动脉上的活动部位是通过对猫进行椎动脉内注射美加明胺而引起的，这引起了低血压并选择性地阻断了来自髓质的电诱发的升压反应，而不影响对乙酰胆碱的“烟碱样”神经节反应。向犬的脑室注射美加明胺会产生低血压，并且抑制迷走神经对传入纤维的刺激和对颈总动脉闭塞的反射性血管舒缩反应，而神经膜对神经节前神经刺激的反应没有任何变化。 。

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