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首页> 美国卫生研究院文献>British Journal of Pharmacology and Chemotherapy >Protective effects of the glucocorticoid budesonide on lung anaphylaxis in actively sensitized guinea-pigs: inhibition of IgE-but not of IgG-mediated anaphylaxis.
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Protective effects of the glucocorticoid budesonide on lung anaphylaxis in actively sensitized guinea-pigs: inhibition of IgE-but not of IgG-mediated anaphylaxis.

机译：糖皮质激素布地奈德对主动致敏的豚鼠肺过敏的保护作用：抑制IgE但不抑制IgG介导的过敏。

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1 The effect of glucocorticoid pretreatment on antigen-induced bronchoconstriction was studied in guinea-pigs actively sensitized to two different ovalbumin regiments (one producing IgE- and IgG-like antibodies and the other exclusively IgG-like antibodies). 2 Budesonide (50 mg/kg) and hydrocortisone (50 mg/kg) given as one intraperitoneal injection 15-20 h before and anaphylactic tests or as two consecutive intraperitoneal injections 5 and 6 days before, led to a decreased bronchial capacity. In this respect glucocorticoid pretreatment was effective only in guinea-pigs sensitized to produce both IgE-like and IgG-like antibodies. 3 Budesonide pretreatment also reduced the capacity of anaphylactically-challenged chopped lung tissue to release histamine in guinea-pigs sensitized to produce both IgE- and IgG-like antibodies. 4 Budesonide pretreatment did not change the levels of circulating IgG1a and IgE-like homocytotropic antibodies as measured by passive cutaneous anaphylaxis; nor did it affect histamine or methacholine-induced bronchoconstriction in vivo or the capacity of histamine or methacholine to contract the guinea-pig isolated trachea preparation of the isoprenaline-induced relaxation of this preparation. 5 The selective inhibitory effects of budesonide and hydrocortisone on IgE-mediated but not IgG-mediated anaphylaxis and the relevance to human atopic disease are discussed.
机译：1在对两种不同的卵清蛋白疗法积极敏感的豚鼠中研究了糖皮质激素预处理对抗原诱导的支气管收缩的作用（一种产生IgE和IgG样抗体，另一种仅产生IgG样抗体）。 2布地奈德（50 mg / kg）和氢化可的松（50 mg / kg）在过敏性试验之前15-20 h进行一次腹膜内注射，或在治疗前5天和6天连续两次进行腹膜内注射，导致支气管容量降低。在这方面，糖皮质激素预处理仅对敏化产生IgE样和IgG样抗体的豚鼠有效。 3布地奈德预处理还降低了过敏性切碎的肺组织释放致敏以产生IgE和IgG样抗体的豚鼠中组胺的能力。 4通过被动皮肤过敏反应测定，布地奈德预处理不会改变循环中的IgG1a和IgE样同嗜细胞抗体的水平；它也不会影响组胺或乙酰甲胆碱在体内引起的支气管收缩，也不会影响组胺或乙酰甲胆碱收缩异丙肾上腺素引起的豚鼠分离的气管制剂的松弛能力。 5讨论了布地奈德和氢化可的松对IgE介导而不是IgG介导的过敏反应的选择性抑制作用以及与人类特应性疾病的相关性。

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