Peristalsis evoked by 5-HT and renzapride: evidence for putative 5-HT4 receptor activation.

机译：5-HT和伦扎必利引起的蠕动：可能的5-HT4受体激活的证据。

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摘要

The effect of 5-hydroxytryptamine and renzapride was studied on the peristaltic reflex elicited in vitro in the guinea-pig ileum. Both agents evoked the reflex at subthreshold intraluminal pressures (50% of threshold) and were blocked by ICS 205-930 (3 microM), but not ondansetron (5 microM). This novel finding suggests strongly that the prokinetic action of renzapride and gut motility stimulating action of 5-hydroxytryptamine are mediated via agonism at the putative 5-HT4 receptor.

机译：研究了5-羟基色胺和伦扎必利对豚鼠回肠体外诱发的蠕动反射的影响。两种药物均在低于阈值的腔内压力（阈值的50％）下引起反射，并被ICS 205-930（3 microM）阻断，但未被昂丹西酮（5 microM）阻断。这个新发现强烈表明，伦扎必利的促运动作用和5-羟色胺的肠蠕动刺激作用是通过对假定的5-HT 4受体的激动作用介导的。

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
D. A. Craig; D. E. Clarke;
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作者单位

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年(卷),期 1991(102),3
年度 1991
页码 563–564
总页数 2
原文格式 PDF
正文语种
中图分类药学;
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1. Evidence for a 5-HT_3 receptor involvement in the facilitation of peristalsis on mucosal application of 5-HT in the guinea pig isolated ileum [J] . B.R.Tuladhar, M.Kaisar, R.J.Naylor British Journal of Pharmacology . 1997,第6期

机译：5-HT_3受体参与促进豚鼠离体回肠粘膜应用5-HT的蠕动的证据
2. In vitro evidence that 5-hydroxytryptamine increases efflux of glial glutamate via 5-HT(2A) receptor activation. [J] . Meller R, Harrison PJ, Elliott JM, Journal of Neuroscience Research . 2002,第3期

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6. Evidence for a 5-HT3 receptor involvement in the facilitation of peristalsis on mucosal application of 5-HT in the guinea pig isolated ileum [O] . B R Tuladhar, M Kaisar, R J Naylor 1997

机译：5-HT3受体参与促进豚鼠离体回肠粘膜应用5-HT的蠕动的证据
7. Peristalsis evoked by 5-HT and renzapride: evidence for putative 5-HT4 receptor activation. [O] . Craig, D. A., Clarke, D. E. 1991

机译：5-HT和伦扎必利引起的蠕动：可能的5-HT4受体激活的证据。

Peristalsis evoked by 5-HT and renzapride: evidence for putative 5-HT4 receptor activation.

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