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首页> 美国卫生研究院文献>British Journal of Pharmacology and Chemotherapy >Effect of lithium on plasma glucose insulin and glucagon in normal and streptozotocin-diabetic rats: role of glucagon in the hyperglycaemic response.
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Effect of lithium on plasma glucose insulin and glucagon in normal and streptozotocin-diabetic rats: role of glucagon in the hyperglycaemic response.

机译：锂对正常和链脲佐菌素-糖尿病大鼠血浆葡萄糖胰岛素和胰高血糖素的影响：胰高血糖素在高血糖反应中的作用。

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摘要

1. Lithium salts, used in the treatment of affective disorders, may have adverse effects on glucose tolerance in man, and suppress glucose-stimulated insulin secretion in rats. 2. To study the interaction of these effects with pre-existing diabetes mellitus, plasma glucose and insulin responses to lithium chloride were measured in male Wistar rats made diabetic with intraperitoneal streptozotocin, and in normal controls. 3. In both normal and diabetic anaesthetized rats, intravenous lithium (4 mEq kg-1) caused a rise in plasma glucose. In absolute terms, the rise was greater in diabetic (5.2 mmol l-1) than in normal rats (2.3 mmol l-1). 4. Plasma insulin concentrations were reduced by lithium in normal rats, but the low insulin concentrations measured in the diabetic rats were not significantly changed. 5. After intravenous glucose (0.5 g kg-1), lithium-treated diabetic rats showed a second rise in plasma glucose at 60-90 min without any insulin response, while normal rats showed typically reduced insulin responses and initial glucose disappearance rates. 6. Intravenous glucose reduced plasma glucagon concentrations to a greater extent in normal than in diabetic rats, but lithium induced an equal rise in plasma glucagon in both groups, with a time-course similar to that of the hyperglycaemic effect. 7. The hyperglycaemic action of lithium is greater in the hypoinsulinaemic diabetic rats and appears to involve a stimulation of glucagon secretion in both normal and diabetic animals.
机译：1.用于治疗情感障碍的锂盐可能会对人的葡萄糖耐量产生不利影响，并抑制大鼠中葡萄糖刺激的胰岛素分泌。 2.为了研究这些作用与先前存在的糖尿病之间的相互作用，在使用腹膜内链脲佐菌素制成糖尿病的雄性Wistar大鼠和正常对照组中，测定了血浆葡萄糖和胰岛素对氯化锂的反应。 3.在正常和糖尿病麻醉大鼠中，静脉内锂（4 mEq kg-1）引起血浆葡萄糖升高。绝对而言，糖尿病患者（5.2 mmol l-1）的升高大于正常大鼠（2.3 mmol l-1）的升高。 4.正常大鼠中锂能降低血浆胰岛素浓度，但在糖尿病大鼠中测得的低胰岛素浓度没有明显改变。 5.静脉注射葡萄糖（0.5 g kg-1）后，用锂治疗的糖尿病大鼠在60-90分钟时血浆葡萄糖出现第二次升高，而没有任何胰岛素反应，而正常大鼠通常显示出胰岛素反应减少和初始葡萄糖消失率降低。 6.正常情况下，静脉葡萄糖降低的血浆胰高血糖素浓度比糖尿病大鼠更大，但是锂诱导两组的血浆胰高血糖素均等升高，其时程与高血糖作用相似。 7.在低胰岛素血症的糖尿病大鼠中锂的高血糖作用更大，并且似乎在正常和糖尿病动物中都刺激胰高血糖素分泌。

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