Kaurane diterpenes protect against apoptosis and inhibition of phagocytosis in activated macrophages

机译：贝壳杉烷二萜类化合物可防止活化巨噬细胞凋亡和抑制吞噬作用

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Background and purpose:The kaurane diterpenes foliol and linearol are inhibitors of the activation of nuclear factor κB, a transcription factor involved in the inflammatory response. Effects of these diterpenes on apoptosis and phagocytosis have been analysed in cultured peritoneal macrophages and in the mouse macrophage cell line, RAW 264.7.

机译：背景与目的：十二烷中的月桂烷二叶醇和线性醇是核因子κB（一种参与炎症反应的转录因子）活化的抑制剂。已经在培养的腹膜巨噬细胞和小鼠巨噬细胞细胞系RAW 264.7中分析了这些二萜对凋亡和吞噬作用的影响。

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
B de las Heras; S Hortelano; N Girón; P Bermejo; B Rodríguez; L Boscá;
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作者单位

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年(卷),期 2007(152),2
年度 2007
页码 249–255
总页数 7
原文格式 PDF
正文语种
中图分类药学;
关键词
foliol linearol macrophages apoptosis nitric oxide lipopolysaccharide interferon-γ phagocytosis;

机译：叶醇;线性醇;巨噬细胞;细胞凋亡;一氧化氮;脂多糖;γ-干扰素;吞噬作用;

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专利

1. Kaurane diterpenes from Isodon japonicus inhibit nitric oxide and prostaglandin E2 production and NF-kappaB activation in LPS-stimulated macrophage RAW264.7 cells. [J] . Hwang BY, Lee JH, Koo TH, Planta medica: Natural products and medicinal plant research . 2001,第5期

机译：Isodon japonicus的铀酰铀酰二萜抑制LPS刺激的巨噬细胞RAW264.7细胞中一氧化氮和前列腺素E2的产生和NF-κB的活化。
2. Inhibition of NF- kappa B activation and iNOS induction by ent-kaurane diterpenoids in LPS-stimulated RAW264.7 murine macrophages. [J] . Aquila S., Weng ZhiYing, Zeng YueQin, Journal of natural products . 2009,第7期

机译：LPS刺激的RAW264.7鼠巨噬细胞中 ent -贝壳杉烷二萜类化合物对NF-κB活化的抑制和iNOS的诱导。
3. Phagocytosis of Apoptotic Cells by Macrophages Induces Novel Signaling Events Leading to Cytokine-Independent Survival and Inhibition of Proliferation: Activation of Akt and Inhibition of Extracellular Signal-Regulated Kinases 1 and 2. [J] . Reddy SM, Abernethy VE, Longacre A, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2002,第2期

机译：巨噬细胞对吞噬细胞的吞噬作用诱导新的信号传导事件，导致细胞因子非依赖性存活和增殖抑制：Akt的激活和细胞外信号调节激酶1和2的抑制。
4. Shape-Induced Inhibition of Phagocytosis by Macrophages [C] . Julie A. Champion, Yogesh Katare, Samir Mitragotri PMSE Symposia . 2007

机译：巨噬细胞的形状诱导抑制吞噬作用
5. Macrophage phagocytosis of polymer microspheres and antitumor activation of macrophages [D] . Tabata, Yasuhiko 1988

机译：聚合物微球的巨噬细胞吞噬作用和巨噬细胞的抗肿瘤活化
6. Extensive Macrophage Accumulation in Young and Old Niemann-Pick C1 model mice involves the alternative M2 activation pathway and inhibition of macrophage apoptosis [O] . Gail Deutsch, Akshay Muralidhar, Ellen Le, -1

机译：老年和老年尼曼-匹克C1模型小鼠中广泛的巨噬细胞积累涉及替代M2激活途径和抑制巨噬细胞凋亡
7. Kaurane diterpenes protect against apoptosis and inhibition of phagocytosis in activated macrophages [O] . Heras, Beatriz de las, Hortelano, Sonsoles, Rodríguez, Benjamín, 2013

机译：贝壳杉烷二萜类化合物可防止活化巨噬细胞凋亡和抑制吞噬作用

Kaurane diterpenes protect against apoptosis and inhibition of phagocytosis in activated macrophages

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