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Dopamine transporter down-regulation following repeated cocaine: implications for 34-methylenedioxymethamphetamine-induced acute effects and long-term neurotoxicity in mice

机译：重复可卡因后多巴胺转运蛋白下调：对小鼠34-亚甲基二氧基甲基苯丙胺诱导的急性效应和长期神经毒性的影响

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Background and purpose:3,4-Methylenedioxymethamphetamine (MDMA) and cocaine are two widely abused psychostimulant drugs targeting the dopamine transporter (DAT). DAT availability regulates dopamine neurotransmission and uptake of MDMA-derived neurotoxic metabolites. We aimed to determine the effect of cocaine pre-exposure on the acute and long-term effects of MDMA in mice.

机译：背景与目的：3,4-亚甲基二氧甲基苯丙胺（MDMA）和可卡因是针对多巴胺转运蛋白（DAT）的两种广泛滥用的精神刺激药物。 DAT的可用性调节多巴胺神经传递和MDMA衍生的神经毒性代谢产物的摄取。我们旨在确定可卡因预暴露对小鼠MDMA的急性和长期作用的影响。

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
I Peraile; E Torres; A Mayado; M Izco; A Lopez-Jimenez; JA Lopez-Moreno; MI Colado; E OShea;
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作者单位

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年(卷),期 2010(159),1
年度 2010
页码 201–211
总页数 11
原文格式 PDF
正文语种
中图分类药学;
关键词
34-methylenedioxymethamphetamine (MDMA ‘ecstasy’) cocaine neurotoxicity dopamine transporter protein kinase C trafficking sensitization;

机译：34-亚甲二氧基甲基苯丙胺（摇头丸）;可卡因;神经毒性;多巴胺转运蛋白;蛋白激酶C;贩运;致敏;

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专利

1. Restoration of cocaine stimulation and reward by reintroducing wild type dopamine transporter in adult knock-in mice with a cocaine-insensitive dopamine transporter [J] . Haiyin Wu, Brian ONeill, Dawn D. Han, Neuropharmacology . 2014,第Null期

机译：通过在可卡因不敏感的多巴胺转运蛋白的成年敲除小鼠中重新引入野生型多巴胺转运蛋白来恢复可卡因的刺激和奖励
2. Role of dopamine neurotransmission in the long-term effects of repeated social defeat on the conditioned rewarding effects of cocaine [J] . Montagud-Romero S., Reguilon M. D., Roger-Sanchez C., Progress in Neuro-Psychopharmacology & Biological Psychiatry: An International Research, Review and News Journal . 2016,第Null期

机译：多巴胺神经传递在反复社交失败对可卡因条件性奖励作用的长期影响中的作用
3. Role of dopamine neurotransmission in the long-term effects of repeated social defeat on the conditioned rewarding effects of cocaine [J] . Montagud-Romero S., Reguilon M. D., Roger-Sanchez C., Progress in Neuro-Psychopharmacology & Biological Psychiatry: An International Research, Review and News Journal . 2016,第Null期

机译：多巴胺神经递质在重复社会失败中对可卡因有益奖励作用的长期影响的作用
4. Utilization of epitope-tagged knock-in mice for IP-MS/MS analysis of the effects of drug treatments on the dopamine transporter interactome [C] . Sarah Rogstad, John Caltagarone, Shiqi MaAlexander Sorkin, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：利用表位标记的敲击小鼠的IP-MS / MS分析药物处理对多巴胺转运蛋白酶的影响
5. The short- and long-term effects of chronic late postnatal blockade of the dopamine transporter on cerebral glucose utilization and dopamine D(1)/D(2) receptors in the rat brain. [D] . Frick, Glen Steven. 1998

机译：慢性后期产后多巴胺转运蛋白对大鼠大脑中葡萄糖利用和多巴胺D（1）/ D（2）受体的慢性短期和长期影响。
6. Restoration of Cocaine Stimulation and Reward by Reintroducing Wild Type Dopamine Transporter in Adult Knock-in Mice with a Cocaine-Insensitive Dopamine Transporter [O] . Haiyin Wu, Brian O’Neill, Dawn D. Han, -1

机译：通过在可卡因不敏感的多巴胺转运蛋白的成年小鼠中重新引入野生型多巴胺转运蛋白来恢复可卡因的刺激和奖励
7. Dopamine transporter down-regulation following repeated cocaine: implications for 3,4-methylenedioxymethamphetamine-induced acute effects and long-term neurotoxicity in mice [O] . Peraile, I, Torres, E, Mayado, A, 2009

机译：重复可卡因后多巴胺转运蛋白下调：对小鼠3,4-亚甲基二氧基甲基苯丙胺诱导的急性效应和长期神经毒性的影响

Dopamine transporter down-regulation following repeated cocaine: implications for 34-methylenedioxymethamphetamine-induced acute effects and long-term neurotoxicity in mice

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